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Anti-HMGB1 Antibody

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产品名称: Anti-HMGB1 Antibody
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简单介绍

Anti-HMGB1 Antibody


Anti-HMGB1 Antibody  的详细介绍
Name: Anti-HMGB1 Antibody
See all HMGB1 primary antibodies
Description: Rabbit monoclonal antibody to HMGB1
Specificity: This antibody detects endogenous levels of HMGB1 and does not cross-react with related proteins.
Applications: WB, ICC/IF, IHC, FC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant antibody.
Host: Rabbit
Clonality: Monoclonal
Conjugate: Unconjugated
Molecular Weight: ~ 25 kDa
Purity: Protein A affinity purified
Product Form: Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Function: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101).
Tissue Specificity: Ubiquituous. Expressed in platelets (PubMed:11154118).
Sequence Similarities: Belongs to the HMGB family.
Post-Translational Modification: Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion (PubMed:17114460).
Cellular Location: Nucleus. Chromosome. Cytoplasm. Secreted. Cell membrane. Endosome. Endoplasmic reticulum-Golgi intermediate compartment.

In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460). Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940). Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity). Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284). Also released from apoptic cells (PubMed:16855214, PubMed:18631454). Active secretion from a variety of immune and non-immune cells such as macrophages, monocytes, neutrophils, dendritic cells and natural killer cells in response to various stimuli such as LPS and cytokines involves a nonconventional secretory process via secretory lysosomes (PubMed:12231511, PubMed:14532127, PubMed:15944249). Secreted by plasma cells in response to LPS (By similarity). Found on the surface of activated platelets (PubMed:11154118).
Database Links:
  • Entrez Gene: 3146?Human
  • Entrez Gene: 100862258?Mouse
  • Entrez Gene: 15289?Mouse
  • Entrez Gene: 25459?Rat
  • Omim: 163905?Human
  • SwissProt: P09429?Human
  • SwissProt: P63158?Mouse
  • SwissProt: P63159?Rat
  • Unigene: 434102?Human
  • Unigene: 593339?Human
  • Unigene: 596078?Human
  • Unigene: 207047?Mouse
  • Unigene: 313345?Mouse
  • Unigene: 144565?Rat
  • Unigene: 15185?Rat
  • Unigene: 4121?Rat
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    Synonyms:
  • Amphoterin Antibody
  • Chromosomal protein, nonhistone, HMG1 Antibody
  • DKFZp686A04236 Antibody
  • High mobility group 1 Antibody
  • High mobility group box 1 Antibody
  • High mobility group protein 1 Antibody
  • High mobility group protein B1 Antibody
  • high-mobility group (nonhistone chromosomal) protein 1 Antibody
  • HMG-1 Antibody
  • HMG1 Antibody
  • HMG3 Antibody
  • HMGB 1 Antibody
  • HMGB1 Antibody
  • HMGB1_HUMAN Antibody
  • NONHISTONE CHROMOSOMAL PROTEIN HMG1 Antibody
  • SBP 1 Antibody
  • Sulfoglucuronyl carbohydrate binding protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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