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Anti-Histone H3.1 (Phospho-Ser10) Antibody

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产品名称: Anti-Histone H3.1 (Phospho-Ser10) Antibody
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简单介绍

Anti-Histone H3.1 (Phospho-Ser10) Antibody


Anti-Histone H3.1 (Phospho-Ser10) Antibody  的详细介绍
Name: Anti-Histone H3.1 (Phospho-Ser10) Antibody
See all Histone H3.1 primary antibodies
Description: Rabbit polyclonal antibody to Histone H3.1 (Phospho-Ser10)
Specificity: The antibody detects endogenous level of Histone H3.1 onlywhen phosphorylated at serine 10.
Applications: WB, IHC, IF
Dilutions: Western blotting: 1:500~1:1000 Immunohistochemistry: 1:50~1:100 Immunofluorescence: 1:100~1:200
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of serine 10 (R-K-S(p)-T-G) derived from Human Histone H3.1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Predicted MW: 17kd
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence Similarities: Belongs to the histone H3 family.
Post-Translational Modification: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
Cellular Location: Nucleus. Chromosome.
Database Links:
  • Entrez Gene: 8350?Human
  • Entrez Gene: 8351?Human
  • Entrez Gene: 8352?Human
  • Entrez Gene: 8353?Human
  • Entrez Gene: 8354?Human
  • Entrez Gene: 8355?Human
  • Entrez Gene: 8356?Human
  • Entrez Gene: 8357?Human
  • Entrez Gene: 8358?Human
  • Entrez Gene: 8968?Human
  • Entrez Gene: 319148?Mouse
  • Entrez Gene: 319151?Mouse
  • Entrez Gene: 319152?Mouse
  • Entrez Gene: 319153?Mouse
  • Entrez Gene: 360198?Mouse
  • Entrez Gene: 97908?Mouse
  • Omim: 602810?Human
  • Omim: 602811?Human
  • Omim: 602812?Human
  • Omim: 602813?Human
  • Omim: 602814?Human
  • Omim: 602815?Human
  • Omim: 602816?Human
  • Omim: 602817?Human
  • Omim: 602818?Human
  • Omim: 602819?Human
  • SwissProt: P68431?Human
  • SwissProt: P68433?Mouse
  • Unigene: 132854?Human
  • Unigene: 247813?Human
  • Unigene: 247814?Human
  • Unigene: 248176?Human
  • Unigene: 443021?Human
  • Unigene: 484990?Human
  • Unigene: 532144?Human
  • Unigene: 533292?Human
  • Unigene: 546315?Human
  • Unigene: 586261?Human
  • Unigene: 591778?Human
  • Unigene: 626666?Human
  • Unigene: 221301?Mouse
  • Unigene: 261657?Mouse
  • Unigene: 377874?Mouse
  • Unigene: 390558?Mouse
  • Unigene: 397328?Mouse
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    Synonyms:
  • H3 histone family, member A Antibody
  • H3 histone family, member B Antibody
  • H3 histone family, member C Antibody
  • H3 histone family, member D Antibody
  • H3 histone family, member E Antibody
  • H3 histone family, member F Antibody
  • H3 histone family, member G Antibody
  • H3 histone family, member H Antibody
  • H3 histone family, member I Antibody
  • H3 histone family, member J Antibody
  • H3 histone family, member K Antibody
  • H3 histone family, member L Antibody
  • H3.1 Antibody
  • H3.f Antibody
  • H3/A Antibody
  • H3/c Antibody
  • H3/d Antibody
  • H3/f Antibody
  • H3/h Antibody
  • H3/i Antibody
  • H3/j Antibody
  • H3/k Antibody
  • H3/l Antibody
  • H31_HUMAN Antibody
  • H3F1K Antibody
  • H3FA Antibody
  • H3FB Antibody
  • H3FC Antibody
  • H3FD Antibody
  • H3FF Antibody
  • H3FH Antibody
  • H3FI Antibody
  • H3FJ Antibody
  • H3FK Antibody
  • H3FL Antibody
  • HIST1 cluster H3A Antibody
  • HIST1 cluster H3B Antibody
  • HIST1 cluster H3C Antibody
  • HIST1 cluster H3D Antibody
  • HIST1 cluster H3E Antibody
  • HIST1 cluster H3F Antibody
  • HIST1 cluster H3G Antibody
  • HIST1 cluster H3I Antibody
  • HIST1 cluster H3J Antibody
  • HIST1H3A Antibody
  • HIST1H3B Antibody
  • HIST1H3C Antibody
  • HIST1H3E Antibody
  • HIST1H3F Antibody
  • HIST1H3G Antibody
  • HIST1H3H Antibody
  • HIST1H3I Antibody
  • HIST1H3J Antibody
  • histone 1, H3a Antibody
  • histone 1, H3b Antibody
  • Histone 1, H3c Antibody
  • Histone 1, H3e Antibody
  • histone 1, H3f Antibody
  • histone 1, H3g Antibody
  • histone 1, H3h Antibody
  • histone 1, H3i Antibody
  • histone 1, H3j Antibody
  • histone cluster 1, H3a Antibody
  • histone cluster 1, H3b Antibody
  • Histone cluster 1, H3c Antibody
  • Histone cluster 1, H3e Antibody
  • histone cluster 1, H3g Antibody
  • histone cluster 1, H3h Antibody
  • histone cluster 1, H3i Antibody
  • histone cluster 1, H3j Antibody
  • Histone gene cluster 1 H3A Antibody
  • Histone gene cluster 1 H3B Antibody
  • Histone gene cluster 1 H3E Antibody
  • Histone gene cluster 1 H3F Antibody
  • Histone gene cluster 1 H3G Antibody
  • Histone gene cluster 1, H3 Antibody
  • Histone gene cluster 1, H3C Antibody
  • Histone gene cluster 1, H3D Antibody
  • Histone gene cluster 1, H3I Antibody
  • Histone gene cluster 1, H3IH Antibody
  • Histone H3.1 Antibody
  • Histone H3/a Antibody
  • Histone H3/b Antibody
  • Histone H3/c Antibody
  • Histone H3/d Antibody
  • Histone H3/f Antibody
  • Histone H3/h Antibody
  • Histone H3/i Antibody
  • Histone H3/j Antibody
  • Histone H3/k Antibody
  • Histone H3/l Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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