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Anti-Histone H2B (K5) Antibody

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产品名称: Anti-Histone H2B (K5) Antibody
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Anti-Histone H2B (K5) Antibody


Anti-Histone H2B (K5) Antibody  的详细介绍
Name: Anti-Histone H2B (K5) Antibody
See all Histone H2B primary antibodies
Description: Rabbit polyclonal antibody to Histone H2B (K5)
Specificity: Histone H2B (K5) pAb detects endogenous levels of Histone H2B protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse
Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human Histone H2B.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 14 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence Similarities: Belongs to the histone H2B family.
Post-Translational Modification: Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
Cellular Location: Nucleus. Chromosome.
Database Links:
  • Entrez Gene: 10339?Human
  • Entrez Gene: 10340?Human
  • Entrez Gene: 337874?Human
  • Entrez Gene: 440689?Human
  • Entrez Gene: 54145?Human
  • Entrez Gene: 8349?Human
  • Entrez Gene: 104021?Mouse
  • Entrez Gene: 319190?Mouse
  • Omim: 601831?Human
  • SwissProt: O60814?Human
  • SwissProt: P06899?Human
  • SwissProt: P23527?Human
  • SwissProt: P33778?Human
  • SwissProt: P57053?Human
  • SwissProt: P58876?Human
  • SwissProt: P62807?Human
  • SwissProt: Q16778?Human
  • SwissProt: Q5QNW6?Human
  • SwissProt: Q8N257?Human
  • SwissProt: Q93079?Human
  • SwissProt: Q99877?Human
  • SwissProt: Q99879?Human
  • SwissProt: Q99880?Human
  • SwissProt: P10854?Mouse
  • SwissProt: Q64475?Mouse
  • SwissProt: Q64524?Mouse
  • Unigene: 473961?Human
  • Unigene: 632451?Human
    		•
    Synonyms:
  • GL105 Antibody
  • H2B Antibody
  • H2B 1A Antibody
  • H2B GL105 Antibody
  • H2B histone family Antibody
  • H2B histone family member O Antibody
  • H2B histone family member Q Antibody
  • H2B histone family member S Antibody
  • H2B type 12 Antibody
  • H2B-GL105 Antibody
  • H2B.1 Antibody
  • H2B.1 B Antibody
  • H2b.1A Antibody
  • H2B.b Antibody
  • H2B.c Antibody
  • H2B.d Antibody
  • H2B.e Antibody
  • H2B.f Antibody
  • H2B.j Antibody
  • H2B.q Antibody
  • H2B/a Antibody
  • H2B/b Antibody
  • H2B/c Antibody
  • H2B/d Antibody
  • H2B/e Antibody
  • H2B/f Antibody
  • H2B/g Antibody
  • H2B/h Antibody
  • H2B/j Antibody
  • H2B/l Antibody
  • H2B/o Antibody
  • H2B/q Antibody
  • H2B1_YEAST Antibody
  • H2B2E_HUMAN Antibody
  • H2B2f Antibody
  • H2B2F_HUMAN Antibody
  • H2Ba Antibody
  • H2Bf Antibody
  • H2BFB Antibody
  • H2BFC Antibody
  • H2BFD Antibody
  • H2BFE Antibody
  • H2BFF Antibody
  • H2BFJ Antibody
  • H2BFO Antibody
  • H2BFQ Antibody
  • H2BFS Antibody
  • H2BGL105 Antibody
  • H2BQ Antibody
  • HIRIP2 Antibody
  • HIST1H2BB Antibody
  • HIST1H2BD Antibody
  • HIST1H2BH Antibody
  • HIST1H2BL Antibody
  • HIST1H2BM Antibody
  • HIST1H2BN Antibody
  • HIST2H2BE Antibody
  • HIST2H2BF Antibody
  • Histone 2 H2be Antibody
  • histone cluster 2, H2be Antibody
  • Histone H2B Antibody
  • histone H2B GL105 Antibody
  • histone H2B type 1 Antibody
  • Histone H2B type 1 B Antibody
  • Histone H2B type 1 D Antibody
  • Histone H2B type 1 H Antibody
  • Histone H2B type 1 L Antibody
  • Histone H2B type 1 M Antibody
  • Histone H2B type 1 N Antibody
  • Histone H2B type 1-B Antibody
  • Histone H2B type 1-C/E/F/G/I Antibody
  • Histone H2B type 1-D Antibody
  • Histone H2B type 1-H Antibody
  • Histone H2B type 1-L Antibody
  • Histone H2B type 1-M Antibody
  • Histone H2B type 1-N Antibody
  • Histone H2B type 2 E Antibody
  • Histone H2B type 2-E Antibody
  • Histone H2B type 2-F Antibody
  • histone H2B type 2E Antibody
  • Histone H2B-GL105 Antibody
  • Histone H2B.1 Antibody
  • Histone H2B.1 A Antibody
  • Histone H2B.2 Antibody
  • Histone H2B.a Antibody
  • Histone H2B.b Antibody
  • Histone H2B.f Antibody
  • Histone H2B.g Antibody
  • Histone H2B.h Antibody
  • Histone H2B.k Antibody
  • Histone H2B.l Antibody
  • Histone H2B.n Antibody
  • Histone H2B.q Antibody
  • histone H2BGL105 Antibody
  • histone protein Antibody
  • HTB 1 Antibody
  • HTB 2 Antibody
  • HTB1 Antibody
  • Htb1p Antibody
  • HTB2 Antibody
  • Htb2p Antibody
  • MGC131639 Antibody
  • SPT 12 Antibody
  • SPT12 Antibody
  • Suppressor of Ty protein 12 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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