产品资料

Anti-GEMIN2 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-GEMIN2 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-GEMIN2 Antibody


Anti-GEMIN2 Antibody  的详细介绍
Name: Anti-GEMIN2 Antibody
See all GEMIN2 primary antibodies
Description: Rabbit polyclonal antibody to GEMIN2.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:1000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide of human GEMIN2.
Protein Length: 280
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Sequence Similarities: Belongs to the gemin-2 family.
Cellular Location: Nucleus > Gem. Cytoplasm.

Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.
Database Links:
  • Entrez Gene: 8487?Human
  • Entrez Gene: 66603?Mouse
  • Entrez Gene: 84404?Rat
  • Omim: 602595?Human
  • SwissProt: O14893?Human
  • SwissProt: Q9CQQ4?Mouse
  • SwissProt: Q9QZP1?Rat
  • Unigene: 652307?Human
  • Unigene: 35353?Mouse
  • Unigene: 34143?Rat
    		•
    Synonyms:
  • Component of gems 2 Antibody
  • Gem (nuclear organelle) associated protein 2 Antibody
  • Gem associated protein 2 Antibody
  • GEMI2_HUMAN Antibody
  • Gemin 2 Antibody
  • Gemin-2 Antibody
  • gemin2 Antibody
  • SIP 1 Antibody
  • SIP-1 Antibody
  • SIP1 Antibody
  • SIP1 delta Antibody
  • SIP1-delta Antibody
  • SMN interacting protein 1 Antibody
  • SMN interacting protein 1 delta Antibody
  • SMN-interacting protein 1 Antibody
  • Survival interacting protein 1 Antibody
  • Survival of motor neuron protein interacting protein 1 Antibody
  • Survival of motor neuron protein-interacting protein 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号