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Anti-DDX1 Antibody

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产品名称: Anti-DDX1 Antibody
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Anti-DDX1 Antibody


Anti-DDX1 Antibody  的详细介绍
Name: Anti-DDX1 Antibody
See all DDX1 primary antibodies
Description: Rabbit polyclonal antibody to DDX1.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human DDX1.
Protein Length: 740
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Required for HIV-1 Rev function as well as for HIV-1 replication. Binds to the RRE sequence of HIV-1 mRNAs.
Tissue Specificity: Highest levels of transcription in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin including the retina, brain, and spinal cord.
Sequence Similarities: Belongs to the DEAD box helicase family. DDX1 subfamily.
Post-Translational Modification: Phosphorylated. Phosphorylated by ATM kinase; phosphorylation is increased in response to ionizing radiation (IR).
Cellular Location: Nucleus. Cytoplasm. Cytoplasmic granule.

Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM-dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Relocalized to the cytoplasm with a perinuclear staining pattern in avian infectious bronchitis virus (IBV)-infected cells. Required for proper localization of HIV-1 Rev. Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264).
Database Links:
  • Entrez Gene: 1653?Human
  • Entrez Gene: 104721?Mouse
  • Entrez Gene: 84474?Rat
  • Omim: 601257?Human
  • SwissProt: Q92499?Human
  • SwissProt: Q91VR5?Mouse
  • SwissProt: Q641Y8?Rat
  • Unigene: 440599?Human
  • Unigene: 251255?Mouse
  • Unigene: 65536?Rat
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    Synonyms:
  • ATP dependent helicase DDX1 Antibody
  • ATP-dependent RNA helicase DDX1 Antibody
  • DBP RB Antibody
  • DBP-RB Antibody
  • DDX1 Antibody
  • DDX1_HUMAN Antibody
  • DEAD (Asp Glu Ala Asp) box polypeptide 1 Antibody
  • DEAD box 1 Antibody
  • DEAD box polypeptide 1 Antibody
  • DEAD box protein 1 Antibody
  • DEAD box protein retinoblastoma Antibody
  • DEAD/H (Asp Glu Ala Asp/His) box polypeptide 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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