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Anti-Cdc20 (Q105) Antibody

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产品名称: Anti-Cdc20 (Q105) Antibody
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Anti-Cdc20 (Q105) Antibody


Anti-Cdc20 (Q105) Antibody  的详细介绍
Name: Anti-Cdc20 (Q105) Antibody
See all Cdc20 primary antibodies
Description: Rabbit polyclonal antibody to Cdc20 (Q105)
Specificity: Cdc20 (Q105) pAb detects endogenous levels of Cdc20 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 80-130 of Human Cdc20.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 55 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Sequence Similarities: Belongs to the WD repeat CDC20/Fizzy family.
Post-Translational Modification: Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
Cellular Location: Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle pole.
Database Links:
  • Entrez Gene: 991?Human
  • Entrez Gene: 107995?Mouse
  • Entrez Gene: 64515?Rat
  • Omim: 603618?Human
  • SwissProt: Q12834?Human
  • SwissProt: Q9JJ66?Mouse
  • SwissProt: Q62623?Rat
  • Unigene: 524947?Human
  • Unigene: 289747?Mouse
  • Unigene: 9262?Rat
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    Synonyms:
  • bA276H19.3 Antibody
  • Cdc 20 Antibody
  • Cdc20 Antibody
  • CDC20 cell division cycle 20 homolog Antibody
  • CDC20A Antibody
  • CDC20_HUMAN Antibody
  • Cell division cycle 20 Antibody
  • Cell division cycle 20 homolog Antibody
  • Cell division cycle 20 homolog (S. cerevisiae) Antibody
  • Cell division cycle protein 20 homolog Antibody
  • fizzy Antibody
  • MGC102824 Antibody
  • p55CDC Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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