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Anti-CD71 Antibody

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产品名称: Anti-CD71 Antibody
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Anti-CD71 Antibody


Anti-CD71 Antibody  的详细介绍
Name: Anti-CD71 Antibody
See all CD71 primary antibodies
Description: Mouse monoclonal (MEM-75) antibody to CD71.
Specificity: The antibody MEM-75 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. The antibody MEM-75 does not block binding of transferrin to the receptor.
Applications: FC, IP, ICC
Reactivity: Human
Immunogen: NALM-6 human pre-B cell line.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-75
Isotype: IgG1
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 98% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 8.0, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal . Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
Involvement in Disease: Immunodeficiency 46: An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia.
Sequence Similarities: Belongs to the peptidase M28 family. M28B subfamily.
Post-Translational Modification: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Cellular Location: Cell membrane. Melanosome.

Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Database Links:
  • Entrez Gene: 7037 Human
  • Omim: 190010 Human
  • SwissProt: P02786 Human
  • Unigene: 529618 Human
    		•
    Synonyms:
  • CD 71 Antibody
  • CD71 Antibody
  • CD71 antigen Antibody
  • IMD46 Antibody
  • OTTHUMP00000208523 Antibody
  • OTTHUMP00000208524 Antibody
  • OTTHUMP00000208525 Antibody
  • p90 Antibody
  • sTfR Antibody
  • T9 Antibody
  • TfR Antibody
  • TFR 1 Antibody
  • TfR1 Antibody
  • TFR1_HUMAN Antibody
  • TFRC Antibody
  • TR Antibody
  • Transferrin Receptor Antibody
  • Transferrin receptor (p90 CD71) Antibody
  • Transferrin receptor protein 1, serum form Antibody
  • Trfr Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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