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Anti-CD41 Antibody

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产品名称: Anti-CD41 Antibody
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简单介绍

Anti-CD41 Antibody


Anti-CD41 Antibody  的详细介绍
Name: Anti-CD41 Antibody
See all CD41 primary antibodies
Description: Rat monoclonal (MWReg30) antibody to CD41.
Specificity: The rat monoclonal antibody MWReg30 recognizes CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Applications: FC, IP, IHC-P, IHC-Fr, ELISA, FUNC
Reactivity: Mouse
Immunogen: Murine platelets.
Host: Rat
Clonality: Monoclonal
Clone: MWReg30
Isotype: IgG1
Conjugate: Unconjugated
Purification: Protein G chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 μm filter sterilised). Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Storage: Store at 2-8°C.
Function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Sequence Similarities: Belongs to the integrin alpha chain family.
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 16399?Mouse
  • SwissProt: Q9QUM0?Mouse
  • Unigene: 26646?Mouse
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    Synonyms:
  • antigen CD41 Antibody
  • BDPLT16 Antibody
  • BDPLT2 Antibody
  • CD41 Antibody
  • CD41B Antibody
  • form 2 Antibody
  • GP2B Antibody
  • GPalpha IIb Antibody
  • GPIIb Antibody
  • GT Antibody
  • GTA Antibody
  • HPA3 Antibody
  • Integrin alpha 2b Antibody
  • Integrin alpha IIb Antibody
  • Integrin alpha-IIb light chain Antibody
  • Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Antibody
  • ITA2B_HUMAN Antibody
  • Itga2b Antibody
  • ITGAB Antibody
  • platelet fibrinogen receptor, alpha subunit Antibody
  • platelet glycoprotein IIb of IIb/IIIa complex Antibody
  • Platelet membrane glycoprotein IIb Antibody
  • platelet specific antigen BAK Antibody
  • PPP1R93 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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