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Anti-CD4 Antibody

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简单介绍

Anti-CD4 Antibody


Anti-CD4 Antibody  的详细介绍
Name: Anti-CD4 Antibody
See all CD4 primary antibodies
Description: Rat monoclonal (GK1.5) antibody to CD4.
Specificity: The rat monoclonal antibody GK1.5 reacts with an extracellular epitope of mouse CD4 transmembrane glycoprotein (55 kDa).
Applications: FC, IP, IHC-Fr, ICC, FUNC
Reactivity: Mouse
Immunogen: Mouse CTL clone V4 cells.
Host: Rat
Clonality: Monoclonal
Clone: GK1.5
Isotype: IgG2b
Conjugate: Unconjugated
Purification: Protein G chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 μm filter sterilised). Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Storage: Store at 2-8°C.
Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Tissue Specificity: Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.
Post-Translational Modification: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 12504?Mouse
  • SwissProt: P06332?Mouse
  • Unigene: 2209?Mouse
    		•
    Synonyms:
  • CD 4 Antibody
  • CD4 Antibody
  • CD4 (L3T4) Antibody
  • CD4 antigen Antibody
  • CD4 antigen (p55) Antibody
  • CD4 molecule Antibody
  • CD4 receptor Antibody
  • CD4+ Lymphocyte deficiency, included Antibody
  • CD4mut Antibody
  • CD4_HUMAN Antibody
  • L3T4 Antibody
  • Leu3 Antibody
  • Ly-4 Antibody
  • Lymphocyte antigen CD4 Antibody
  • MGC165891 Antibody
  • OTTHUMP00000238897 Antibody
  • p55 Antibody
  • T cell antigen T4 Antibody
  • T cell antigen T4/LEU3 Antibody
  • T cell differentiation antigen L3T4 Antibody
  • T cell OKT4 deficiency, included Antibody
  • T cell surface antigen T4/Leu 3 Antibody
  • T cell surface antigen T4/Leu3 Antibody
  • T cell surface glycoprotein CD4 Antibody
  • T-cell surface antigen T4/Leu-3 Antibody
  • T-cell surface glycoprotein CD4 Antibody
  • W3/25 Antibody
  • W3/25 antigen Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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