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Anti-CD29 Antibody

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产品名称: Anti-CD29 Antibody
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Anti-CD29 Antibody


Anti-CD29 Antibody  的详细介绍
Name: Anti-CD29 Antibody
See all Integrin beta 1 primary antibodies
Description: Mouse monoclonal (MEM-101A) antibody to CD29 (FITC).
Specificity: The antibody MEM-101A reacts with CD29 (integrin beta1 chain), a 130 kDa single chain type I glycoprotein expressed as a heterodimer (non-covalently associated with the integrin alpha subunits 1-6). CD29 is broadly expressed on majority of hematopoietic and non-hematopoietic cells (leukocytes, platelets, fibroblasts, endothelial cells, epithelial cells and mast cells).
Applications: FC, IP, WB
Reactivity: Human, Porcine, Dog
Immunogen: Raji Burkitt's lymphoma cell line.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-101A
Isotype: IgG1
Conjugate: FITC
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage: Store in the dark at 2-8°C. Avoid prolonged exposure to light.
Function: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation (By similarity). Is involved in rejection of pig-to-human tissue xenografts. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand- (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity).
Tissue Specificity: Widely expressed.
Sequence Similarities: Belongs to the integrin beta chain family.
Post-Translational Modification: The cysteine residues are involved in intrachain disulfide bonds.
Cellular Location: Cell membrane. Cell projection > Invadopodium membrane. Cell projection > Ruffle membrane. Recycling endosome. Melanosome. Cell projection > Lamellipodium. Cell projection > Ruffle. Cell junction > Focal adhesion. Cell surface.

Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions to fibrillar adhesions in an ITGB1BP1-dependent manner.
Database Links:
  • Entrez Gene: 3688 Human
  • Entrez Gene: 397019 Pig
  • Omim: 135630 Human
  • SwissProt: P05556 Human
  • SwissProt: Q9GLP0 Pig
  • Unigene: 643813 Human
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    Synonyms:
  • beta1 integrin Antibody
  • CD29 Antibody
  • Fibronectin receptor subunit beta Antibody
  • FNRB Antibody
  • Glycoprotein IIa Antibody
  • GP IIa Antibody
  • GPIIA Antibody
  • Integrin beta 1 Antibody
  • Integrin beta-1 Antibody
  • Integrin subunit beta 1 Antibody
  • integrin VLA-4 beta subunit Antibody
  • Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) Antibody
  • ITB1_HUMAN Antibody
  • ITGB1 Antibody
  • MDF2 Antibody
  • MSK12 Antibody
  • OTTHUMP00000019420 Antibody
  • Very late activation protein, beta polypeptide Antibody
  • VLA BETA Antibody
  • VLA-4 subunit beta Antibody
  • VLA-BETA Antibody
  • VLAB Antibody
  • VLAbeta Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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