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Anti-CD28 Antibody

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产品名称: Anti-CD28 Antibody
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简单介绍

Anti-CD28 Antibody


Anti-CD28 Antibody  的详细介绍
Name: Anti-CD28 Antibody
See all CD28 primary antibodies
Description: Mouse monoclonal (CD28.2) antibody to CD28 (PerCP).
Specificity: The antibody CD28.2 reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells.
Applications: FC, IP, WB, IHC-Fr, ICC, FUNC
Reactivity: Human, Non-Human Primates
Immunogen: DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA.
Host: Mouse
Clonality: Monoclonal
Clone: CD28.2
Isotype: IgG1
Conjugate: PerCP
Purification: Size exclusion chromatography.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage: Store in the dark at 2-8°C. Avoid prolonged exposure to light.
Function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).
Tissue Specificity: Expressed in T-cells and plasma cells, but not in less mature B-cells.
Post-Translational Modification: CD40LG induces tyrosine phosphorylation of isoform 3.
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 940?Human
  • Omim: 186760?Human
  • SwissProt: P10747?Human
  • Unigene: 591629?Human
    		•
    Synonyms:
  • CD 28 Antibody
  • CD28 Antibody
  • CD28 antigen Antibody
  • CD28 molecule Antibody
  • CD28_HUMAN Antibody
  • MGC138290 Antibody
  • T cell antigen CD28 Antibody
  • T cell specific surface glycoprotein Antibody
  • T cell specific surface glycoprotein CD28 Antibody
  • T-cell-specific surface glycoprotein CD28 Antibody
  • TP44 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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