产品资料

Anti-ADAM17 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-ADAM17 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-ADAM17 Antibody


Anti-ADAM17 Antibody  的详细介绍
Name: Anti-ADAM17 Antibody
See all ADAM17 primary antibodies
Description: Goat polyclonal antibody to ADAM17.
Applications: ELISA, WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human ADAM17 (C terminal).
Sequence: LQRQNRVDSKETEC
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Tissue Specificity: Ubiquitously expressed. Expressed at highest levels in ***** heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Involvement in Disease: Inflammatory skin and bowel disease, neonatal, 1: A disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized.
Post-Translational Modification: The precursor is cleaved by a furin endopeptidase.
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 6868?Human
  • Omim: 603639?Human
  • SwissProt: P78536?Human
  • Unigene: 404914?Human
    		•
    Synonyms:
  • A disintegrin and metalloproteinase domain 17 Antibody
  • A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) Antibody
  • ADA17_HUMAN Antibody
  • ADAM 17 Antibody
  • ADAM metallopeptidase domain 17 Antibody
  • ADAM17 Antibody
  • ADAM17 protein Antibody
  • CD 156b Antibody
  • CD156b Antibody
  • CD156b antigen Antibody
  • CSVP Antibody
  • Disintegrin and metalloproteinase domain-containing protein 17 Antibody
  • MGC71942 Antibody
  • NISBD Antibody
  • NISBD1 Antibody
  • Snake venom like protease Antibody
  • Snake venom-like protease Antibody
  • TACE Antibody
  • TNF alpha convertase Antibody
  • TNF alpha converting enzyme Antibody
  • TNF-alpha convertase Antibody
  • TNF-alpha-converting enzyme Antibody
  • Tumor Necrosis Factor Alpha Converting Enzyme Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号