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Anti-TP53BP1 Antibody

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产品名称: Anti-TP53BP1 Antibody
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简单介绍

Anti-TP53BP1 Antibody


Anti-TP53BP1 Antibody  的详细介绍
Name: Anti-TP53BP1 Antibody
See all TP53BP1 primary antibodies
Description: Rabbit polyclonal antibody to TP53BP1.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human TP53BP1.
Protein Length: 1972 (1977)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.
Post-Translational Modification: Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.
Cellular Location: Nucleus. Chromosome > Centromere > Kinetochore.

Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed.
Database Links:
  • Entrez Gene: 7158?Human
  • Entrez Gene: 27223?Mouse
  • Entrez Gene: 296099?Rat
  • Omim: 605230?Human
  • SwissProt: Q12888?Human
  • SwissProt: P70399?Mouse
  • Unigene: 440968?Human
  • Unigene: 383499?Mouse
  • Unigene: 481841?Mouse
    		•
    Synonyms:
  • 53 BP1 Antibody
  • 53BP1 Antibody
  • FLJ41424 Antibody
  • MGC138366 Antibody
  • p202 Antibody
  • p53 binding protein 1 Antibody
  • p53 BP1 Antibody
  • p53-binding protein 1 Antibody
  • p53BP1 Antibody
  • TP53 BP1 Antibody
  • Tp53bp1 Antibody
  • TP53B_HUMAN Antibody
  • TRP53 BP1 Antibody
  • Tumor protein 53 binding protein 1 Antibody
  • Tumor protein p53 binding protein 1 Antibody
  • Tumor suppressor p53 binding protein 1 Antibody
  • Tumor suppressor p53-binding protein 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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