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Anti-SUMO-1 Antibody

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产品名称: Anti-SUMO-1 Antibody
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Anti-SUMO-1 Antibody


Anti-SUMO-1 Antibody  的详细介绍
Name: Anti-SUMO-1 Antibody
See all SUMO-1 primary antibodies
Description: Rabbit monoclonal antibody to SUMO-1.
Applications: WB, IHC, IF, IP, FC, ChIP
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IF: 1:50 - 1:100, IP: 1:20 - 1:50, FC: 1:20 - 1:50.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human SUMO1.
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).
Involvement in Disease: Non-syndromic orofacial cleft 10: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
Sequence Similarities: Belongs to the ubiquitin family. SUMO subfamily.
Post-Translational Modification: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
Cellular Location: Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus > PML body. Cell membrane. Nucleus.

Recruited by BCL11A into the nuclear body. In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body.
Database Links:
  • Entrez Gene: 7341?Human
  • Entrez Gene: 22218?Mouse
  • Entrez Gene: 301442?Rat
  • Omim: 601912?Human
  • SwissProt: P63165?Human
  • SwissProt: P63166?Mouse
  • SwissProt: Q5I0H3?Rat
  • Unigene: 596171?Human
  • Unigene: 81424?Human
  • Unigene: 362118?Mouse
  • Unigene: 1221?Rat
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    Synonyms:
  • DAP1 Antibody
  • GAP modifying protein 1 Antibody
  • GAP-modifying protein 1 Antibody
  • GMP 1 Antibody
  • GMP1 Antibody
  • OFC10 Antibody
  • PIC 1 Antibody
  • PIC1 Antibody
  • SENP2 Antibody
  • Sentrin Antibody
  • Sentrin 1 Antibody
  • Small ubiquitin related modifier 1 Antibody
  • Small ubiquitin-like modifier 1 Antibody
  • Small ubiquitin-related modifier 1 Antibody
  • SMT3 Antibody
  • SMT3 homolog 3 Antibody
  • SMT3 suppressor of mif two 3 homolog 1 Antibody
  • SMT3, yeast, homolog 3 Antibody
  • Smt3C Antibody
  • SMT3H3 Antibody
  • Sumo 1 Antibody
  • SUMO-1 Antibody
  • SUMO1 Antibody
  • SUMO1_HUMAN Antibody
  • Ubiquitin homology domain protein PIC1 Antibody
  • Ubiquitin Like 1 Antibody
  • Ubiquitin like protein SMT3C Antibody
  • Ubiquitin like protein UBL1 Antibody
  • Ubiquitin-homology domain protein PIC1 Antibody
  • Ubiquitin-like protein SMT3C Antibody
  • Ubiquitin-like protein UBL1 Antibody
  • UBL 1 Antibody
  • UBL1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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