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Anti-SMAD9 Antibody

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产品名称: Anti-SMAD9 Antibody
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简单介绍

Anti-SMAD9 Antibody


Anti-SMAD9 Antibody  的详细介绍
Name: Anti-SMAD9 Antibody
See all SMAD9 primary antibodies
Description: Rabbit polyclonal antibody to SMAD9.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human SMAD9.
Protein Length: 467 (430)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
Tissue Specificity: Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.
Involvement in Disease: Pulmonary hypertension, primary, 2: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
Sequence Similarities: Belongs to the dwarfin/SMAD family.
Post-Translational Modification: Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
Cellular Location: Cytoplasm. Nucleus.

In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).
Database Links:
  • Entrez Gene: 4093?Human
  • Entrez Gene: 55994?Mouse
  • Entrez Gene: 85435?Rat
  • Omim: 603295?Human
  • SwissProt: O15198?Human
  • SwissProt: Q9JIW5?Mouse
  • SwissProt: O54835?Rat
  • Unigene: 123119?Human
  • Unigene: 244353?Mouse
  • Unigene: 10862?Rat
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    Synonyms:
  • MAD homolog 9 Antibody
  • Madh6 Antibody
  • Mothers against decapentaplegic Antibody
  • Mothers against decapentaplegic homolog 9 Antibody
  • Mothers against DPP homolog 9 Antibody
  • SMAD 9 Antibody
  • SMAD family member 9 Antibody
  • SMAD, mothers against DPP homolog 9 (Drosophila) Antibody
  • SMAD8A Antibody
  • SMAD8B Antibody
  • SMAD9 Antibody
  • SMAD9_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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