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Anti-SH3BP1 Antibody

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产品名称: Anti-SH3BP1 Antibody
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简单介绍

Anti-SH3BP1 Antibody


Anti-SH3BP1 Antibody  的详细介绍
Name: Anti-SH3BP1 Antibody
See all SH3BP1 primary antibodies
Description: Goat polyclonal antibody to SH3BP1.
Applications: ELISA, WB, IHC, ICC, IF
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human SH3BP1 (C terminal).
Sequence: C-PQPRPRSLASETN
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563).
Cellular Location: Cell projection. Cell junction > Tight junction. Cell junction > Adherens junction. Cell projection > Phagocytic cup. Nucleus. Cytoplasm > Cytosol.

Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563). Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210).
Database Links:
  • Entrez Gene: 23616?Human
  • SwissProt: Q9Y3L3?Human
  • Unigene: 601143?Human
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    Synonyms:
  • 3BP 1 Antibody
  • 3BP-1 Antibody
  • 3BP1_HUMAN Antibody
  • ARHGAP43 Antibody
  • dJ37E16 Antibody
  • FLJ21318 Antibody
  • OTTHUMP00000028981 Antibody
  • SH3 domain binding protein 1 Antibody
  • SH3 domain-binding protein 1 Antibody
  • SH3BP1 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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