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Anti-PPP1R8 Antibody

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产品名称: Anti-PPP1R8 Antibody
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Anti-PPP1R8 Antibody


Anti-PPP1R8 Antibody  的详细介绍
Name: Anti-PPP1R8 Antibody
See all PPP1R8 primary antibodies
Description: Rabbit polyclonal antibody to PPP1R8.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human PPP1R8.
Protein Length: 351 (209)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Tissue Specificity: Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells.
Post-Translational Modification: May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity). Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA.
Cellular Location: Nucleus. Nucleus speckle.

Primarily, but not exclusively, nuclear.
Database Links:
  • Entrez Gene: 5511?Human
  • Entrez Gene: 100336?Mouse
  • Entrez Gene: 313030?Rat
  • Omim: 602636?Human
  • SwissProt: Q12972?Human
  • SwissProt: Q8R3G1?Mouse
  • Unigene: 533474?Human
  • Unigene: 105230?Mouse
  • Unigene: 16580?Rat
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    Synonyms:
  • Activator of RNA decay Antibody
  • ARD 1 Antibody
  • ARD-1 Antibody
  • ARD1 Antibody
  • Homolog of E.coli RNase E Antibody
  • NIPP 1 Antibody
  • NIPP-1 Antibody
  • NIPP1 Antibody
  • Nuclear inhibitor of protein phosphatase 1 Antibody
  • nuclear inhibitor of protein phosphatase-1 alpha Antibody
  • Nuclear subunit of PP1 Antibody
  • PP1R8_HUMAN Antibody
  • PPP1R8 Antibody
  • PRO2047 Antibody
  • Protein phosphatase 1 regulatory inhibitor subunit 8 Antibody
  • Protein phosphatase 1 regulatory subunit 8 Antibody
  • RNase E Antibody
  • RNase E, E. coli, homolog of Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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