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Anti-Notch 1 Antibody

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产品名称: Anti-Notch 1 Antibody
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Anti-Notch 1 Antibody


Anti-Notch 1 Antibody  的详细介绍
Name: Anti-Notch 1 Antibody
See all Notch1 primary antibodies
Description: Mouse monoclonal (mN1A) antibody to Notch 1.
Specificity: The mouse monoclonal antibody mN1A recognizes intracellular domain of Notch 1 protein, mainly its activated form. The unprocessed Notch 1 protein is recognized with lower affinity.
Applications: FC, IP, WB, IHC-Fr, ICC
Reactivity: Human, Mouse
Immunogen: GST fusion protein containing cdc10-NCR region of mouse Notch1.
Host: Mouse
Clonality: Monoclonal
Clone: mN1A
Isotype: IgG1
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Tissue Specificity: Highly expressed in the brain, lung and thymus. Expressed at lower levels in the spleen, bone-marrow, spinal cord, eyes, mammary gland, liver, intestine, skeletal muscle, kidney and heart. In the hair follicle, highly expressed exclusively in the epithelial compartment.
Sequence Similarities: Belongs to the NOTCH family.
Post-Translational Modification: Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by ADAM17 to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). Following endocytosis, this fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 4851?Human
  • Entrez Gene: 18128?Mouse
  • Omim: 190198?Human
  • SwissProt: P46531?Human
  • SwissProt: Q01705?Mouse
  • Unigene: 495473?Human
  • Unigene: 290610?Mouse
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    Synonyms:
  • 9930111A19Rik Antibody
  • AOS5 Antibody
  • AOVD1 Antibody
  • hN1 Antibody
  • Lin-12 Antibody
  • LIN12 Antibody
  • Mis6 Antibody
  • Motch A Antibody
  • mT14 Antibody
  • Neurogenic locus notch homolog protein 1 Antibody
  • Neurogenic locus notch protein homolog Antibody
  • NICD Antibody
  • NOTC1_HUMAN Antibody
  • NOTCH Antibody
  • Notch 1 Antibody
  • Notch 1 intracellular domain Antibody
  • Notch gene homolog 1 (Drosophila) Antibody
  • Notch homolog 1, translocation-associated (Drosophila) Antibody
  • NOTCH, Drosophila, homolog of, 1 Antibody
  • Notch1 Antibody
  • TAN1 Antibody
  • Translocation associated notch homolog Antibody
  • Translocation associated notch protein TAN 1 Antibody
  • Translocation-associated notch protein TAN-1 Antibody
  • xotch Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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