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Anti-Nephrin Antibody

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产品名称: Anti-Nephrin Antibody
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Anti-Nephrin Antibody


Anti-Nephrin Antibody  的详细介绍
Name: Anti-Nephrin Antibody
See all Nephrin primary antibodies
Description: Rabbit monoclonal (Y17-R) antibody to NEPHRIN.
Specificity: This antibody recognizes the epitope located between Cys465 - Cys528.
Applications: WB, ELISA, IP, ICC
Dilutions: WB: 1:5,000. ELISA: 1:50,000-1:100,000.
Reactivity: Human, Mouse, Rat
Immunogen: Peptide derived from the centre of the fifth Ig-like domain of human nephrin.
Host: Rabbit
Clonality: Monoclonal
Clone: Y17-R
Isotype: IgG
Conjugate: Unconjugated
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 8.0, with 10 mg/ml BSA & 0.05% Sodium Azide.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity).
Tissue Specificity: Specifically expressed in podocytes of kidney glomeruli.
Involvement in Disease: Nephrotic syndrome 1: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.
Sequence Similarities: Belongs to the immunoglobulin superfamily.
Post-Translational Modification: Phosphorylated at Tyr-1193 by FYN, leading to the recruitment and activation of phospholipase C-gamma-1/PLCG1.
Cellular Location: Cell membrane.

Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane.
Database Links:
  • Entrez Gene: 4868 Human
  • Entrez Gene: 54631 Mouse
  • Entrez Gene: 64563 Rat
  • Omim: 602716 Human
  • SwissProt: O60500 Human
  • SwissProt: Q9QZS7 Mouse
  • SwissProt: Q9R044 Rat
  • Unigene: 122186 Human
  • Unigene: 437830 Mouse
  • Unigene: 48745 Rat
    		•
    Synonyms:
  • CNF Antibody
  • Nephrin Antibody
  • Nephrosis 1 congenital Finnish type Antibody
  • Nephrosis 1, congenital, Finnish type (nephrin) Antibody
  • NPHN Antibody
  • NPHN_HUMAN Antibody
  • NPHS 1 Antibody
  • Nphs1 Antibody
  • Renal glomerulus specific cell adhesion receptor Antibody
  • Renal glomerulus-specific cell adhesion receptor Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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