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Anti-LIG3 Antibody

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产品名称: Anti-LIG3 Antibody
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Anti-LIG3 Antibody


Anti-LIG3 Antibody  的详细介绍
Name: Anti-LIG3 Antibody
See all LIG3 primary antibodies
Description: Rabbit polyclonal antibody to LIG3.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human LIG3.
Protein Length: 1009
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).
Tissue Specificity: Testis, thymus, prostate and heart.
Sequence Similarities: Belongs to the ATP-dependent DNA ligase family.
Cellular Location: Mitochondrion.

Contains an N-terminal mitochondrial transit peptide.
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