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Anti-IRF6 Antibody

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产品名称: Anti-IRF6 Antibody
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Anti-IRF6 Antibody


Anti-IRF6 Antibody  的详细介绍
Name: Anti-IRF6 Antibody
See all IRF6 primary antibodies
Description: Goat polyclonal antibody to IRF6.
Applications: ELISA, WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human IRF6 (C terminal).
Sequence: C-TPSMQLPPALPPQ
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity).
Tissue Specificity: Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.
Involvement in Disease: Van der Woude syndrome 1: An autosomal dominant developmental disorder characterized by lower lip pits, cleft lip and/or cleft palate.

Popliteal pterygium syndrome: An autosomal dominant disorder characterized by oro-facial, skin and genital anomalies. Expressivity is variable. Clinical features include cleft lip/palate, lower lip cysts, syngnathia, congenital ankyloblepharon filiforme in some cases, bifid scrotum, hypoplastic scrotum, hypoplastic uterus, talipes equinovarus.

Non-syndromic orofacial cleft 6: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
Sequence Similarities: Belongs to the IRF family.
Post-Translational Modification: Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.
Cellular Location: Nucleus. Cytoplasm.

Translocates to nucleus in response to an activating signal.
Database Links:
  • Entrez Gene: 3664?Human
  • Omim: 607199?Human
  • SwissProt: O14896?Human
  • Unigene: 591415?Human
  • Unigene: 719361?Human
    		•
    Synonyms:
  • Interferon regulatory factor 6 Antibody
  • IRF 6 Antibody
  • IRF-6 Antibody
  • IRF6 Antibody
  • IRF6_HUMAN Antibody
  • LPS Antibody
  • OFC 6 Antibody
  • OFC6 Antibody
  • OTTHUMP00000034677 Antibody
  • OTTHUMP00000034678 Antibody
  • PIT Antibody
  • PPS Antibody
  • PPS1 Antibody
  • VWS Antibody
  • VWS1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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