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Anti-Glucose Transporter GLUT1 Antibody

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产品名称: Anti-Glucose Transporter GLUT1 Antibody
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Anti-Glucose Transporter GLUT1 Antibody


Anti-Glucose Transporter GLUT1 Antibody  的详细介绍
Name: Anti-Glucose Transporter GLUT1 Antibody
See all Glucose Transporter GLUT1 primary antibodies
Description: Rabbit monoclonal antibody to Glucose Transporter GLUT1.
Applications: WB, IHC, IF, FC
Dilutions: WB: 1:500 - 1:1000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IF: 1:50 - 1:200, FC: 1:10 - 1:50.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human SLC2A1.
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
Tissue Specificity: Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues.
Involvement in Disease: GLUT1 deficiency syndrome 1: A neurologic disorder showing wide phenotypic variability. The most severe 'classic' phenotype comprises infantile-onset epileptic encephalopathy associated with delayed development, acquired microcephaly, motor incoordination, and spasticity. Onset of seizures, usually characterized by apneic episodes, staring spells, and episodic eye movements, occurs within the first 4 months of life. Other paroxysmal findings include intermittent ataxia, confusion, lethargy, sleep disturbance, and headache. Varying degrees of cognitive impairment can occur, ranging from learning disabilities to severe mental retardation.

GLUT1 deficiency syndrome 2: A clinically variable disorder characterized primarily by onset in childhood of paroxysmal exercise-induced dyskinesia. The dyskinesia involves transient abnormal involuntary movements, such as dystonia and choreoathetosis, induced by exercise or exertion, and affecting the exercised limbs. Some patients may also have epilepsy, most commonly childhood absence epilepsy. Mild mental retardation may also occur. In some patients involuntary exertion-induced dystonic, choreoathetotic, and ballistic movements may be associated with macrocytic hemolytic anemia.

Epilepsy, idiopathic generalized 12: A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Seizure types include juvenile myoclonic seizures, absence seizures, and generalized tonic-clonic seizures. In some EIG12 patients seizures may remit with age.

Dystonia 9: An autosomal dominant neurologic disorder characterized by childhood onset of paroxysmal choreoathetosis and progressive spastic paraplegia. Most patients show some degree of cognitive impairment. Other variable features may include seizures, migraine headaches, and ataxia.

Stomatin-deficient cryohydrocytosis with neurologic defects: A rare form of stomatocytosis characterized by episodic hemolytic anemia, cold-induced red cells cation leak, erratic hyperkalemia, neonatal hyperbilirubinemia, hepatosplenomegaly, cataracts, seizures, mental retardation, and movement disorder.
Sequence Similarities: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Cellular Location: Cell membrane. Melanosome.

Localizes primarily at the cell surface. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Database Links:
  • Entrez Gene: 6513?Human
  • Entrez Gene: 20525?Mouse
  • Entrez Gene: 24778?Rat
  • Omim: 138140?Human
  • SwissProt: P11166?Human
  • SwissProt: P17809?Mouse
  • SwissProt: P11167?Rat
  • Unigene: 473721?Human
  • Unigene: 721551?Human
  • Unigene: 21002?Mouse
  • Unigene: 3205?Rat
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    Synonyms:
  • Choreoathetosis/spasticity episodic (paroxysmal choreoathetosis/spasticity) Antibody
  • CSE Antibody
  • DYT17 Antibody
  • DYT18 Antibody
  • DYT9 Antibody
  • EIG12 Antibody
  • erythrocyte/brain Antibody
  • Erythrocyte/hepatoma glucose transporter Antibody
  • facilitated glucose transporter member 1 Antibody
  • Glucose transporter 1 Antibody
  • Glucose Transporter GLUT1 Antibody
  • Glucose transporter type 1 Antibody
  • Glucose transporter type 1, erythrocyte/brain Antibody
  • GLUT Antibody
  • GLUT-1 Antibody
  • GLUT1 Antibody
  • GLUT1DS Antibody
  • GLUTB Antibody
  • GT1 Antibody
  • GTG1 Antibody
  • Gtg3 Antibody
  • GTR1_HUMAN Antibody
  • HepG2 glucose transporter Antibody
  • HTLVR Antibody
  • Human T cell leukemia virus (I and II) receptor Antibody
  • MGC141895 Antibody
  • MGC141896 Antibody
  • PED Antibody
  • RATGTG1 Antibody
  • Receptor for HTLV 1 and HTLV 2 Antibody
  • SLC2A1 Antibody
  • Solute carrier family 2 Antibody
  • Solute carrier family 2 (facilitated glucose transporter), member 1 Antibody
  • Solute carrier family 2, facilitated glucose transporter member 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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