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Anti-DDX5 Antibody

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产品名称: Anti-DDX5 Antibody
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简单介绍

Anti-DDX5 Antibody


Anti-DDX5 Antibody  的详细介绍
Name: Anti-DDX5 Antibody
See all DDX5 primary antibodies
Description: Rabbit polyclonal antibody to DDX5.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human DDX5.
Protein Length: 614
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
Sequence Similarities: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
Post-Translational Modification: Arg-502 is dimethylated, probably to asymmetric dimethylarginine.
Cellular Location: Nucleus > Nucleolus.
Database Links:
  • Entrez Gene: 1655?Human
  • Entrez Gene: 13207?Mouse
  • Entrez Gene: 287765?Rat
  • Omim: 180630?Human
  • SwissProt: P17844?Human
  • SwissProt: Q61656?Mouse
  • Unigene: 279806?Human
  • Unigene: 220038?Mouse
  • Unigene: 162208?Rat
    		•
    Synonyms:
  • ATP dependent RNA helicase DDX5 Antibody
  • DDX 5 Antibody
  • DDX5 Antibody
  • DDX5_HUMAN Antibody
  • DEAD (Asp Glu Ala Asp) box helicase 5 Antibody
  • DEAD (Asp Glu Ala Asp) box polypeptide 5 Antibody
  • DEAD box 5 Antibody
  • DEAD box protein 5 Antibody
  • DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5 (RNA helicase, 68kD) Antibody
  • G17P1 Antibody
  • HELR Antibody
  • HLR1 Antibody
  • HUMP68 Antibody
  • P68 Antibody
  • p68 RNA helicase Antibody
  • Probable ATP dependent RNA helicase DDX5 Antibody
  • Probable ATP-dependent RNA helicase DDX5 Antibody
  • RNA helicase p68 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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