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Anti-CREBBP Antibody

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产品名称: Anti-CREBBP Antibody
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Anti-CREBBP Antibody


Anti-CREBBP Antibody  的详细介绍
Name: Anti-CREBBP Antibody
See all CREBBP primary antibodies
Description: Rabbit polyclonal antibody to CREBBP.
Applications: WB
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity: Human, Mouse
Immunogen: Recombinant protein of human CREBBP.
Protein Length: 2442
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).
Involvement in Disease: Rubinstein-Taybi syndrome 1: A disorder characterized by craniofacial abnormalities, postnatal growth deficiency, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
Post-Translational Modification: Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response (By similarity).
Cellular Location: Cytoplasm. Nucleus.

Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
Database Links:
  • Entrez Gene: 1387?Human
  • Entrez Gene: 12914?Mouse
  • Omim: 600140?Human
  • SwissProt: Q92793?Human
  • SwissProt: P45481?Mouse
  • Unigene: 459759?Human
  • Unigene: 132238?Mouse
  • Unigene: 392384?Mouse
    		•
    Synonyms:
  • CBP Antibody
  • CBP_HUMAN Antibody
  • CREB binding protein Antibody
  • CREB-binding protein Antibody
  • Crebbp Antibody
  • Cyclic AMP responsive enhancer binding protein Antibody
  • KAT3A Antibody
  • KAT3A / CBP Antibody
  • RSTS Antibody
  • RTS Antibody
  • Rubinstein Taybi syndrome Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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