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Anti-CD4 (A429) Antibody

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产品名称: Anti-CD4 (A429) Antibody
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Anti-CD4 (A429) Antibody


Anti-CD4 (A429) Antibody  的详细介绍
Name: Anti-CD4 (A429) Antibody
See all CD4 primary antibodies
Description: Rabbit polyclonal antibody to CD4 (A429)
Specificity: CD4 (A429) pAb detects endogenous levels of CD4 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse
Immunogen: Synthetic peptide, corresponding to amino acids 391-440 of Human CD4.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 51 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Post-Translational Modification: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular Location: Cell membrane.

Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Database Links:
  • Entrez Gene: 920?Human
  • Entrez Gene: 12504?Mouse
  • Omim: 186940?Human
  • SwissProt: P01730?Human
  • SwissProt: P06332?Mouse
  • Unigene: 631659?Human
  • Unigene: 2209?Mouse
    		•
    Synonyms:
  • CD 4 Antibody
  • CD4 Antibody
  • CD4 (L3T4) Antibody
  • CD4 antigen Antibody
  • CD4 antigen (p55) Antibody
  • CD4 molecule Antibody
  • CD4 receptor Antibody
  • CD4+ Lymphocyte deficiency, included Antibody
  • CD4mut Antibody
  • CD4_HUMAN Antibody
  • L3T4 Antibody
  • Leu3 Antibody
  • Ly-4 Antibody
  • Lymphocyte antigen CD4 Antibody
  • MGC165891 Antibody
  • OTTHUMP00000238897 Antibody
  • p55 Antibody
  • T cell antigen T4 Antibody
  • T cell antigen T4/LEU3 Antibody
  • T cell differentiation antigen L3T4 Antibody
  • T cell OKT4 deficiency, included Antibody
  • T cell surface antigen T4/Leu 3 Antibody
  • T cell surface antigen T4/Leu3 Antibody
  • T cell surface glycoprotein CD4 Antibody
  • T-cell surface antigen T4/Leu-3 Antibody
  • T-cell surface glycoprotein CD4 Antibody
  • W3/25 Antibody
  • W3/25 antigen Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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