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Anti-CD18 Antibody

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产品名称: Anti-CD18 Antibody
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简单介绍

Anti-CD18 Antibody


Anti-CD18 Antibody  的详细介绍
Name: Anti-CD18 Antibody
See all CD18 primary antibodies
Description: Mouse monoclonal (MEM-48) antibody to CD18.
Specificity: The antibody MEM-48 recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit; beta2 integrin). CD18 is a 90-95 kDa type I transmembrane protein expressed on all leukocytes.
Applications: FC, IP, WB, IHC-P, IHC-Fr, FUNC
Reactivity: Human
Immunogen: Leukocytes from a patient suffering from a LGL Type leukemia.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-48
Isotype: IgG1
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Tissue Specificity: Leukocytes.
Involvement in Disease: Leukocyte adhesion deficiency 1: LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
Sequence Similarities: Belongs to the integrin beta chain family.
Post-Translational Modification: Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305). Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335).
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 3689?Human
  • Omim: 600065?Human
  • SwissProt: P05107?Human
  • Unigene: 375957?Human
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    Synonyms:
  • 95 subunit beta Antibody
  • Beta 2 (antigen CD18 (p95) Antibody
  • CD 18 Antibody
  • CD18 Antibody
  • Cell surface adhesion glycoprotein LFA 1/CR3/P150,959 beta subunit precursor) Antibody
  • Cell surface adhesion glycoproteins LFA 1/CR3/p150,95 subunit beta Antibody
  • Cell surface adhesion glycoproteins LFA-1/CR3/p150 Antibody
  • Complement component 3 receptor 3 and 4 subunit Antibody
  • Complement receptor C3 beta subunit Antibody
  • Complement receptor C3 subunit beta Antibody
  • Integrin beta 2 Antibody
  • Integrin beta chain beta 2 Antibody
  • Integrin beta-2 Antibody
  • Integrin beta-2 (ITGB2) Antibody
  • Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) Antibody
  • ITB2_HUMAN Antibody
  • ITGB2 Antibody
  • LAD Antibody
  • LCAMB Antibody
  • Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C Antibody
  • Leukocyte cell adhesion molecule CD18 Antibody
  • LFA 1 Antibody
  • LFA1 Antibody
  • Lymphocyte function associated antigen 1 Antibody
  • Lymphocyte function associated antigen 1 (LFA1) Antibody
  • MAC 1 Antibody
  • MAC1 Antibody
  • Macrophage antigen 1 (mac1) beta Antibody
  • MF17 Antibody
  • MFI7 Antibody
  • OTTHUMP00000115278 Antibody
  • OTTHUMP00000115279 Antibody
  • OTTHUMP00000115280 Antibody
  • OTTHUMP00000115281 Antibody
  • OTTHUMP00000115282 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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