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Anti-CD163 Antibody

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产品名称: Anti-CD163 Antibody
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Anti-CD163 Antibody


Anti-CD163 Antibody  的详细介绍
Name: Anti-CD163 Antibody
See all CD163 primary antibodies
Description: Rabbit monoclonal (K20-T) antibody to CD163.
Specificity: This antibody recognizes the epitope between Gly134 - Gly148.
Applications: IHC-P, IHC-Fr
Dilutions: IHC: 1:100-1:200.
Reactivity: Human
Immunogen: Peptide derived from N-terminal sequence of human CD163.
Host: Rabbit
Clonality: Monoclonal
Clone: K20-T
Isotype: IgG
Conjugate: Unconjugated
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 8.0, with 20 mg/ml BSA & 0.05% Sodium Azide.
Storage: Store at 4°C.
Function: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
Tissue Specificity: Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
Post-Translational Modification: A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs.
Cellular Location: Secreted.
Database Links:
  • Entrez Gene: 9332?Human
  • Omim: 605545?Human
  • SwissProt: Q86VB7?Human
  • Unigene: 504641?Human
    		•
    Synonyms:
  • C163A_HUMAN Antibody
  • CD 163 Antibody
  • CD163 Antibody
  • CD163 antigen Antibody
  • CD163 molecule Antibody
  • Hemoglobin scavenger receptor Antibody
  • M130 Antibody
  • M130 antigen precursor Antibody
  • Macrophage associated antigen Antibody
  • MM130 Antibody
  • OTTHUMP00000238617 Antibody
  • OTTHUMP00000238618 Antibody
  • OTTHUMP00000238619 Antibody
  • OTTHUMP00000238620 Antibody
  • SCARI1 Antibody
  • Scavenger receptor cysteine rich type 1 protein M130 Antibody
  • sCD163 Antibody
  • Soluble CD163 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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