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Anti-CD105 Antibody

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Anti-CD105 Antibody


Anti-CD105 Antibody  的详细介绍
Name: Anti-CD105 Antibody
See all CD105 primary antibodies
Description: Mouse monoclonal (MEM-229) antibody to CD105 (FITC).
Specificity: The antibody MEM-229 recognizes CD105 (Endoglin), a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and ***** bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Applications: FC, WB, IHC-Fr, ICC
Reactivity: Human, Porcine
Immunogen: Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-229
Isotype: IgG2a
Conjugate: FITC
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage: Store in the dark at 2-8°C. Avoid prolonged exposure to light.
Function: Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.
Tissue Specificity: Endoglin is restricted to endothelial cells in all tissues except bone marrow.
Involvement in Disease: Telangiectasia, hereditary hemorrhagic, 1: A multisystemic vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera. The disease is characterized by recurrent epistaxis and gastro-intestinal hemorrhage. Visceral involvement includes arteriovenous malformations of the lung, liver, and brain.
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 2022?Human
  • Omim: 131195?Human
  • SwissProt: P17813?Human
  • Unigene: 76753?Human
    		•
    Synonyms:
  • AI528660 Antibody
  • AI662476 Antibody
  • CD 105 Antibody
  • CD105 Antibody
  • CD105 antigen Antibody
  • EGLN_HUMAN Antibody
  • END Antibody
  • Endoglin Antibody
  • Eng Antibody
  • FLJ41744 Antibody
  • HHT1 Antibody
  • ORW Antibody
  • ORW1 Antibody
  • Osler Rendu Weber syndrome 1 Antibody
  • RP11 228B15.2 Antibody
  • S-endoglin Antibody
  • SN6 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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