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Anti-Alkaline Phosphatase Antibody

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Anti-Alkaline Phosphatase Antibody


Anti-Alkaline Phosphatase Antibody  的详细介绍
Name: Anti-Alkaline Phosphatase Antibody
See all Alkaline Phosphatase primary antibodies
Description: Rabbit monoclonal antibody to Alkaline Phosphatase.
Applications: WB, IHC, IF, IP, FC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IP: 1:20 - 1:50, FC: 1:10 - 1:50.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human ALPL.
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: This isozyme may play a role in skeletal mineralization.
Involvement in Disease: Hypophosphatasia: A metabolic bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Four forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and ***** type. The perinatal form is the most severe and is almost always fatal. The ***** form is mild and characterized by recurrent fractures, osteomalacia, rickets, and loss of teeth. Some cases are asymptomatic, while some patients manifest dental features without skeletal manifestations (odontohypophosphatasia).

Hypophosphatasia childhood type: A bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase.

Hypophosphatasia infantile type: A severe bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Three more or less distinct types of infantile hypophosphatasia can be identified: (1) type 1 with onset in utero or in early postnatal life, craniostenosis, severe skeletal abnormalities, hypercalcemia, and death in the first year or so of life; (2) type 2 with later, more gradual development of symptoms, moderately severe 'rachitic' skeletal changes and premature loss of teeth; (3) type 3 with no symptoms, the condition being determined on routine studies.
Sequence Similarities: Belongs to the alkaline phosphatase family.
Post-Translational Modification: N-glycosylated.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 248?Human
  • Entrez Gene: 249?Human
  • Entrez Gene: 250?Human
  • Entrez Gene: 251?Human
  • Entrez Gene: 11647?Mouse
  • Entrez Gene: 76768?Mouse
  • Entrez Gene: 24197?Rat
  • Entrez Gene: 25586?Rat
  • Omim: 171740?Human
  • Omim: 171760?Human
  • Omim: 171800?Human
  • Omim: 171810?Human
  • SwissProt: P05186?Human
  • SwissProt: P05187?Human
  • SwissProt: P09923?Human
  • SwissProt: P10696?Human
  • SwissProt: P09242?Mouse
  • SwissProt: P24822?Mouse
  • SwissProt: P08289?Rat
  • SwissProt: P15693?Rat
  • Unigene: 284255?Human
  • Unigene: 37009?Human
  • Unigene: 75431?Human
  • Unigene: 377076?Mouse
    		•
    Synonyms:
  • Alkaline phosphatase, germ cell Antibody
  • Alkaline phosphatase, testicular and thymus Antibody
  • Akp2 Antibody
  • Alkaline Phosphatase Antibody
  • Alkaline phosphatase intestinal Antibody
  • Alkaline phosphatase intestinal precursor Antibody
  • Alkaline phosphatase liver/bone/kidney Antibody
  • Alkaline phosphatase liver/bone/kidney isozyme Antibody
  • Alkaline phosphatase placental Antibody
  • Alkaline phosphatase placental like Antibody
  • Alkaline phosphatase placental like 2 Antibody
  • Alkaline phosphatase placental type Antibody
  • Alkaline phosphatase tissue nonspecific isozyme Antibody
  • Alkaline phosphatase, liver Antibody
  • Alkaline phosphatase, tissue-nonspecific Antibody
  • Alkaline phosphomonoesterase Antibody
  • ALP Antibody
  • ALP 1 Antibody
  • ALP I Antibody
  • ALP L Antibody
  • ALP P Antibody
  • ALPG Antibody
  • Alpi Antibody
  • ALPL Antibody
  • ALPP Antibody
  • ALPPL Antibody
  • ALPPL2 Antibody
  • AP TNAP Antibody
  • FLJ40094 Antibody
  • GCAP Antibody
  • Germ cell alkaline phosphatase Antibody
  • Glycerophosphatase Antibody
  • HOPS Antibody
  • IAP Antibody
  • Intestinal alkaline phosphatase Antibody
  • Intestinal-type alkaline phosphatase Antibody
  • Kasahara isozyme Antibody
  • Liver/bone/kidney type alkaline phosphatase Antibody
  • Nagao isozyme Antibody
  • OTTHUMP00000164357 Antibody
  • Placental alkaline phosphatase Antibody
  • Placental like alkaline phosphatase Antibody
  • PLAP Antibody
  • PLAP 1 Antibody
  • PLAP like Antibody
  • PPBI_HUMAN Antibody
  • Regan isozyme Antibody
  • Testicular and thymus alkaline phosphatase Antibody
  • Tissue non specific alkaline phosphatase Antibody
  • Tissue nonspecific ALP Antibody
  • TNAP Antibody
  • TNSALP Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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