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Anti-SILV Antibody

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产品名称: Anti-SILV Antibody
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简单介绍

Anti-SILV Antibody


Anti-SILV Antibody  的详细介绍
Name: Anti-SILV Antibody
See all SILV primary antibodies
Description: Goat polyclonal antibody to SILV.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human SILV (C terminal).
Sequence: CPIGENSPLLSGQQ
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
Tissue Specificity: Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas. Normally expressed at low levels in quiescent ***** melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth.
Sequence Similarities: Belongs to the PMEL/NMB family.
Post-Translational Modification: A small amount of P1/P100 (major form) undergoes glycosylation to yield P2/P120 (minor form). P2 is cleaved by a furin-like proprotein convertase (PC) in a pH-dependent manner in a post-Golgi, prelysosomal compartment into two disulfide-linked subunits: a large lumenal subunit, M-alpha/ME20-S, and an integral membrane subunit, M-beta. Despite cleavage, only a small fraction of M-alpha is secreted, whereas most M-alpha and M-beta remain associated with each other intracellularly. M-alpha is further processed to M-alpha N and M-alpha C. M-alpha C further undergoes processing to yield M-alpha C1 and M-alpha C3 (M-alpha C2 in the case of PMEL17-is or PMEL17-ls). Formation of intralumenal fibrils in the melanosomes requires the formation of M-alpha that becomes incorporated into the fibrils. Stage II melanosomes harbor only Golgi-modified Pmel17 fragments that are derived from M-alpha and that bear sialylated O-linked oligosaccharides.
Cellular Location: Endoplasmic reticulum membrane. Golgi apparatus. Melanosome. Endosome > Multivesicular body.

Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes.
Database Links:
  • Entrez Gene: 6490 Human
  • Omim: 155550 Human
  • SwissProt: P40967 Human
  • Unigene: 95972 Human
    		•
    Synonyms:
  • 95 kDa melanocyte specific secreted glycoprotein Antibody
  • 95 kDa melanocyte-specific secreted glycoprotein Antibody
  • D12S53E Antibody
  • gp100 Antibody
  • M-beta Antibody
  • ME20 Antibody
  • ME20 M/ME20 S Antibody
  • ME20-M Antibody
  • ME20-S Antibody
  • ME20M Antibody
  • ME20M/ME20S Antibody
  • ME20S Antibody
  • Melanocyte lineage specific antigen GP100 Antibody
  • Melanocyte protein mel 17 Antibody
  • Melanocyte protein Pmel 17 Antibody
  • Melanocyte protein Pmel 17 precursor Antibody
  • Melanocytes lineage-specific antigen GP100 Antibody
  • Melanoma associated ME20 antigen Antibody
  • Melanoma gp100 Antibody
  • Melanoma-associated ME20 antigen Antibody
  • Melanosomal matrix protein 17 Antibody
  • Melanosomal matrix protein17 Antibody
  • P1 Antibody
  • p100 Antibody
  • p26 Antibody
  • PMEL Antibody
  • PMEL 17 Antibody
  • PMEL17 Antibody
  • PMEL_HUMAN Antibody
  • Premelanosome protein Antibody
  • Secreted melanoma-associated ME20 antigen Antibody
  • SI Antibody
  • SIL Antibody
  • SILV Antibody
  • Silver (mouse homolog) like Antibody
  • Silver homolog Antibody
  • Silver locus protein homolog Antibody
  • Silver, mouse, homolog of Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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