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Anti-SHP1 Antibody

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产品名称: Anti-SHP1 Antibody
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简单介绍

Anti-SHP1 Antibody


Anti-SHP1 Antibody  的详细介绍
Name: Anti-SHP1 Antibody
See all SHP1 primary antibodies
Description: Rabbit monoclonal antibody to SHP1
Specificity: This antibody detects endogenous levels of SHP1 and does not cross-react with related proteins.
Applications: WB, ICC/IF, IHC, FC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant antibody.
Host: Rabbit
Clonality: Monoclonal
Conjugate: Unconjugated
Molecular Weight: ~ 68 kDa
Purity: Protein A affinity purified
Product Form: Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Function: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Tissue Specificity: Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Sequence Similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Post-Translational Modification: Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.
Cellular Location: Cytoplasm. Nucleus.

In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.
Database Links:
  • Entrez Gene: 5777?Human
  • Entrez Gene: 15170?Mouse
  • Entrez Gene: 116689?Rat
  • Omim: 176883?Human
  • SwissProt: P29350?Human
  • SwissProt: P29351?Mouse
  • SwissProt: P81718?Rat
  • Unigene: 63489?Human
  • Unigene: 271799?Mouse
  • Unigene: 18985?Rat
    		•
    Synonyms:
  • 70Z-SHP Antibody
  • EC 3.1.3.48 Antibody
  • HCP Antibody
  • HCPH Antibody
  • Hematopoietic cell phosphatase Antibody
  • Hematopoietic cell protein tyrosine phosphatase Antibody
  • Hematopoietic cell protein-tyrosine phosphatase Antibody
  • HPTP1C Antibody
  • Protein tyrosine phosphatase 1C Antibody
  • Protein tyrosine phosphatase non receptor type 6 Antibody
  • Protein tyrosine phosphatase SHP1 Antibody
  • Protein-tyrosine phosphatase 1C Antibody
  • protein-tyrosine phosphatase SHP 1 Antibody
  • Protein-tyrosine phosphatase SHP-1 Antibody
  • PTN6_HUMAN Antibody
  • PTP 1C Antibody
  • PTP-1C Antibody
  • PTP1C Antibody
  • Ptpn6 Antibody
  • SH PTP 1 Antibody
  • SH PTP1 Antibody
  • SH-PTP1 Antibody
  • SHP 1 Antibody
  • SHP 1L Antibody
  • SHP1 Antibody
  • SHP1L Antibody
  • tyrosine protein phosphatase non receptor type 6 Antibody
  • Tyrosine-protein phosphatase non-receptor type 6 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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