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Anti-RNF2 Antibody

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产品名称: Anti-RNF2 Antibody
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Anti-RNF2 Antibody


Anti-RNF2 Antibody  的详细介绍
Name: Anti-RNF2 Antibody
See all RNF2 primary antibodies
Description: Rabbit polyclonal antibody to RNF2.
Applications: WB, IHC, IF, IP, ChIP
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:50 - 1:200, ChIP: 1:20 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human RNF2.
Protein Length: 336
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.
Post-Translational Modification: Polyubiquitinated in the presence of UBE2D3 (in vitro).
Cellular Location: Nucleus. Chromosome.

Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (By similarity).
Database Links:
  • Entrez Gene: 6045?Human
  • Entrez Gene: 19821?Mouse
  • Entrez Gene: 304850?Rat
  • Omim: 608985?Human
  • SwissProt: Q99496?Human
  • SwissProt: Q9CQJ4?Mouse
  • SwissProt: Q4KLY4?Rat
  • Unigene: 591490?Human
  • Unigene: 482250?Mouse
  • Unigene: 19719?Rat
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    Synonyms:
  • BAP 1 Antibody
  • BAP1 Antibody
  • DING Antibody
  • DinG protein Antibody
  • E3 ubiquitin protein ligase RING 2 Antibody
  • E3 ubiquitin protein ligase RING2 Antibody
  • E3 ubiquitin-protein ligase RING2 Antibody
  • HIP2 interacting protein 3 Antibody
  • HIP2-interacting protein 3 Antibody
  • HIPI 3 Antibody
  • HIPI3 Antibody
  • Huntingtin interacting protein 2 interacting protein 3 Antibody
  • Huntingtin-interacting protein 2-interacting protein 3 Antibody
  • OTTHUMP00000060668 Antibody
  • Polycomb M33 interacting protein Ring 1B Antibody
  • Polycomb M33 interacting protein Ring1B Antibody
  • Protein DinG Antibody
  • RING 1B Antibody
  • RING 2 Antibody
  • RING finger protein 1B Antibody
  • RING finger protein 2 Antibody
  • RING finger protein BAP 1 Antibody
  • RING finger protein BAP-1 Antibody
  • RING finger protein BAP1 Antibody
  • RING1b Antibody
  • RING2 / RING1B / RNF2 Antibody
  • RING2_HUMAN Antibody
  • RNF 2 Antibody
  • Rnf2 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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