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Anti-PRDM1 Antibody

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产品名称: Anti-PRDM1 Antibody
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简单介绍

Anti-PRDM1 Antibody


Anti-PRDM1 Antibody  的详细介绍
Name: Anti-PRDM1 Antibody
See all PRDM1 primary antibodies
Description: Goat polyclonal antibody to PRDM1.
Applications: ELISA, WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human PRDM1 (C terminal).
Sequence: C-KVKQETVEPMDP
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).
Sequence Similarities: Belongs to the class V-like SAM-binding methyltransferase superfamily.
Post-Translational Modification: Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation.
Cellular Location: Nucleus. Cytoplasm.
Database Links:
  • Entrez Gene: 639?Human
  • Omim: 603423?Human
  • SwissProt: O75626?Human
  • Unigene: 436023?Human
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    Synonyms:
  • B Lymphocyte Induced Maturation Protein 1 Antibody
  • Beta interferon gene positive regulatory domain I binding factor Antibody
  • Beta-interferon gene positive regulatory domain I-binding factor Antibody
  • BLIMP-1 Antibody
  • BLIMP1 Antibody
  • Positive Regulatory Domain I Binding Factor 1 Antibody
  • Positive regulatory domain I-binding factor 1 Antibody
  • PR Domain Containing 1 Antibody
  • PR domain containing 1 with ZNF domain Antibody
  • PR domain containing 1 with ZNF domain isoform 2 Antibody
  • PR domain containing protein 1 Antibody
  • PR domain zinc finger protein 1 Antibody
  • PR domain-containing protein 1 Antibody
  • PRDI BF1 Antibody
  • PRDI binding factor 1 Antibody
  • PRDI-BF1 Antibody
  • PRDI-binding factor 1 Antibody
  • PRDM 1 Antibody
  • Prdm1 Antibody
  • PRDM1/Blimp1 Antibody
  • PRDM1_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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