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Anti-ANLN Antibody

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产品名称: Anti-ANLN Antibody
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简单介绍

Anti-ANLN Antibody


Anti-ANLN Antibody  的详细介绍
Name: Anti-ANLN Antibody
See all ANLN primary antibodies
Description: Goat polyclonal antibody to ANLN.
Applications: ELISA, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human ANLN (C terminal).
Sequence: WQPDACYKPIGKP
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. May play a significant role in podocyte cell migration (PubMed:24676636).
Tissue Specificity: Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Involvement in Disease: Focal segmental glomerulosclerosis 8: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Post-Translational Modification: Phosphorylated during mitosis.
Cellular Location: Nucleus. Cytoplasm > Cytoskeleton. Cytoplasm > Cell cortex.

Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
Database Links:
  • Entrez Gene: 54443?Human
  • Omim: 616027?Human
  • SwissProt: Q9NQW6?Human
  • Unigene: 62180?Human
    		•
    Synonyms:
  • Actin binding protein anillin Antibody
  • Actin binding protein scraps homolog Drosophila Antibody
  • Actin-binding protein anillin Antibody
  • Anillin Antibody
  • Anillin actin binding protein Antibody
  • anln Antibody
  • ANLN_HUMAN Antibody
  • DKFZp779A055 Antibody
  • FSGS8 Antibody
  • Scra Antibody
  • Scraps Antibody
  • Scraps homolog Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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