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Anti-14-3-3 ζ (W228) Antibody

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产品名称: Anti-14-3-3 ζ (W228) Antibody
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Anti-14-3-3 ζ (W228) Antibody


Anti-14-3-3 ζ (W228) Antibody  的详细介绍
Name: Anti-14-3-3 ζ (W228) Antibody
See all 14-3-3 ζ primary antibodies
Description: Rabbit polyclonal antibody to 14-3-3 ζ (W228)
Specificity: 14-3-3 ζ (W228) pAb detects endogenous levels of 14-3-3 protein zeta/delta.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 200-250 of Human 14-3-3 ζ.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 28 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Sequence Similarities: Belongs to the 14-3-3 family.
Post-Translational Modification: The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53.
Cellular Location: Cytoplasm. Melanosome.

Located to stage I to stage IV melanosomes.
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