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Anti-STAT1 Antibody

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Anti-STAT1 Antibody


Anti-STAT1 Antibody  的详细介绍
Name: Anti-STAT1 Antibody
See all STAT1 primary antibodies
Description: Mouse monoclonal (SM1) antibody to STAT1.
Specificity: The antibody SM1 recognizes an epitope included within amino acids 721-733 of STAT1, a 91 kDa transcriptional factor involved in a variety of systems including antiviral responses and interferon alpha (IFN-alpha) and gamma (IFN-gamma) signal transduction.
Applications: IP, WB, IHC-P
Reactivity: Mouse, Human
Immunogen: STAT1 peptide sequence 721-733 (DNLLPMSPEEFDE).
Host: Mouse
Clonality: Monoclonal
Clone: SM1
Isotype: IgG2b
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Sequence Similarities: Belongs to the transcription factor STAT family.
Post-Translational Modification: Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including IFN-alpha, IFN-gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1, JAK2 or TYK2 promotes dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates STAT1 signaling only via JAK2. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMKII on IFN-gamma stimulation, regulates STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though increasing interaction with PIAS. Phosphorylation on Ser-727 by PRKCD induces apoptosis in response to DNA-damaging agents. Phosphorylated on tyrosine residues when PTK2/FAK1 is activated; most likely this is catalyzed by a SRC family kinase. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates interferon-mediated signaling. Upon viral infection or IFN induction, phosphorylation on Ser-708 occurs much later than phosphorylation on Tyr-701 and is required for the binding of ISGF3 on the ISREs of a subset of IFN-stimulated genes IKBKE-dependent. Phosphorylation at Tyr-701 and Ser-708 are mutually exclusive, phosphorylation at Ser-708 requires previous dephosphorylation of Tyr-701.
Cellular Location: Cytoplasm. Nucleus.

Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus. Translocates into the nucleus in response to interferon-beta stimulation.
Database Links:
  • Entrez Gene: 6772?Human
  • Entrez Gene: 20846?Mouse
  • Omim: 600555?Human
  • SwissProt: P42224?Human
  • SwissProt: P42225?Mouse
  • Unigene: 642990?Human
  • Unigene: 743244?Human
  • Unigene: 277406?Mouse
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    Synonyms:
  • Signal transducer and activator of transcription 1 91kD Antibody
  • CANDF7 Antibody
  • DKFZp686B04100 Antibody
  • IMD31A Antibody
  • IMD31B Antibody
  • IMD31C Antibody
  • ISGF 3 Antibody
  • ISGF-3 Antibody
  • OTTHUMP00000163552 Antibody
  • OTTHUMP00000165046 Antibody
  • OTTHUMP00000165047 Antibody
  • OTTHUMP00000205845 Antibody
  • Signal transducer and activator of transcription 1 Antibody
  • Signal transducer and activator of transcription 1 91kDa Antibody
  • Signal transducer and activator of transcription 1, 91kD Antibody
  • Signal transducer and activator of transcription 1-alpha/beta Antibody
  • STAT 1 Antibody
  • STAT1 Antibody
  • STAT1_HUMAN Antibody
  • STAT91 Antibody
  • Transcription factor ISGF 3 components p91 p84 Antibody
  • Transcription factor ISGF-3 components p91/p84 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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