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Anti-SFN Antibody

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产品名称: Anti-SFN Antibody
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简单介绍

Anti-SFN Antibody


Anti-SFN Antibody  的详细介绍
Name: Anti-SFN Antibody
See all SFN primary antibodies
Description: Rabbit polyclonal antibody to SFN.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human SFN.
Protein Length: 248
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Tissue Specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Sequence Similarities: Belongs to the 14-3-3 family.
Post-Translational Modification: Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
Cellular Location: Cytoplasm. Nucleus. Secreted.

May be secreted by a non-classical secretory pathway.
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