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Anti-IRS-1 (phospho-S307) Antibody

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产品名称: Anti-IRS-1 (phospho-S307) Antibody
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Anti-IRS-1 (phospho-S307) Antibody


Anti-IRS-1 (phospho-S307) Antibody  的详细介绍
Name: Anti-IRS-1 (phospho-S307) Antibody
See all IRS-1 primary antibodies
Description: Rabbit polyclonal antibody to IRS-1 (phospho-S307)
Specificity: P-IRS-1 (S307) pAb detects endogenous levels of IRS-1 protein only when phosphorylated at Ser307
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human IRS-1 around the phosphorylation site of Serine 307.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~132, 180 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Involvement in Disease: Diabetes mellitus, non-insulin-dependent: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Post-Translational Modification: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity). Phosphorylated by ALK. Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1.
Database Links:
  • Entrez Gene: 3667?Human
  • Entrez Gene: 16367?Mouse
  • Entrez Gene: 25467?Rat
  • Omim: 147545?Human
  • SwissProt: P35568?Human
  • SwissProt: P35569?Mouse
  • SwissProt: P35570?Rat
  • Unigene: 471508?Human
  • Unigene: 4952?Mouse
  • Unigene: 10476?Rat
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    Synonyms:
  • HIRS 1 Antibody
  • HIRS1 Antibody
  • Insulin receptor substrate 1 Antibody
  • IRS 1 Antibody
  • IRS-1 Antibody
  • IRS1 Antibody
  • IRS1_HUMAN Antibody
  • OTTHUMP00000164234 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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