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Anti-COL1A2 (S3) Antibody

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产品名称: Anti-COL1A2 (S3) Antibody
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Anti-COL1A2 (S3) Antibody


Anti-COL1A2 (S3) Antibody  的详细介绍
Name: Anti-COL1A2 (S3) Antibody
See all COL1A2 primary antibodies
Description: Rabbit polyclonal antibody to COL1A2 (S3)
Specificity: COL1A2 (S3) pAb detects endogenous levels of Collagen alpha-2(I) chain protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to the N-terminus of Human COL1A2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 125 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Type I collagen is a member of group I collagen (fibrillar forming collagen).
Tissue Specificity: Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
Involvement in Disease: Ehlers-Danlos syndrome 7B: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. Marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations.

Osteogenesis imperfecta 1: An autosomal dominant form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI1 is a non-deforming form with normal height or mild short stature, and no dentinogenesis imperfecta.

Osteogenesis imperfecta 2: An autosomal dominant form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI2 is characterized by bone fragility, with many perinatal fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to respiratory insufficiency.

Ehlers-Danlos syndrome, autosomal recessive, cardiac valvular form: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. In addition to joint laxity, skin hyperextensibility and friability, and abnormal scar formation, patients have mitral valve prolapse and insufficiency, mitral regurgitation, and aortic insufficiency.

Osteogenesis imperfecta 3: An autosomal dominant form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI3 is characterized by progressively deforming bones, very short stature, a triangular face, severe scoliosis, grayish sclera and dentinogenesis imperfecta.

Osteogenesis imperfecta 4: An autosomal dominant form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI4 is characterized by moderately short stature, mild to moderate scoliosis, grayish or white sclera and dentinogenesis imperfecta.
Sequence Similarities: Belongs to the fibrillar collagen family.
Post-Translational Modification: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Cellular Location: Secreted > Extracellular space > Extracellular matrix.
Database Links:
  • Entrez Gene: 1278?Human
  • Entrez Gene: 12843?Mouse
  • Entrez Gene: 84352?Rat
  • Omim: 120160?Human
  • SwissProt: P08123?Human
  • SwissProt: Q01149?Mouse
  • SwissProt: P02466?Rat
  • Unigene: 489142?Human
  • Unigene: 277792?Mouse
  • Unigene: 107239?Rat
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    Synonyms:
  • Alpha 2 collagen type I Antibody
  • Alpha 2 type I collagen Antibody
  • Alpha 2 type I procollagen Antibody
  • Alpha 2(I) collagen Antibody
  • Alpha 2(I) procollagen Antibody
  • Alpha-2 type I collagen Antibody
  • CO1A2_HUMAN Antibody
  • COL1A2 Antibody
  • Collagen alpha 2(I) chain Antibody
  • Collagen alpha-2(I) chain Antibody
  • Collagen I alpha 2 polypeptide Antibody
  • Collagen of skin tendon and bone alpha 2 chain Antibody
  • Collagen type I alpha 2 Antibody
  • OI4 Antibody
  • Osteogenesis imperfecta type IV Antibody
  • Type I procollagen Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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