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Anti-Smad4 (L43) Antibody

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产品名称: Anti-Smad4 (L43) Antibody
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Anti-Smad4 (L43) Antibody


Anti-Smad4 (L43) Antibody  的详细介绍
Name: Anti-Smad4 (L43) Antibody
See all Smad4 primary antibodies
Description: Rabbit polyclonal antibody to Smad4 (L43)
Specificity: Smad4 (L43) pAb detects endogenous levels of Smad4 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids12-64 of Human Smad4.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 60 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Involvement in Disease: Pancreatic cancer: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

Juvenile polyposis syndrome: Autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers.

Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome: JP/HHT syndrome phenotype consists of the coexistence of juvenile polyposis (JIP) and hereditary hemorrhagic telangiectasia (HHT) [MIM:187300] in a single individual. JIP and HHT are autosomal dominant disorders with distinct and non-overlapping clinical features. The former, an inherited gastrointestinal malignancy predisposition, is caused by mutations in SMAD4 or BMPR1A, and the latter is a vascular malformation disorder caused by mutations in ENG or ACVRL1. All four genes encode proteins involved in the transforming-growth-factor-signaling pathway. Although there are reports of patients and families with phenotypes of both disorders combined, the genetic etiology of this association is unknown.

Colorectal cancer: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.

Myhre syndrome: A syndrome characterized by pre- and postnatal growth deficiency, mental retardation, generalized muscle hypertrophy and striking muscular build, decreased joint mobility, cryptorchidism, and unusual facies. Dysmorphic facial features include microcephaly, midface hypoplasia, prognathism, and blepharophimosis. Typical skeletal anomalies are short stature, square body shape, broad ribs, iliac hypoplasia, brachydactyly, flattened vertebrae, and thickened calvaria. Other features, such as congenital heart disease, may also occur.
Sequence Similarities: Belongs to the dwarfin/SMAD family.
Post-Translational Modification: Phosphorylated by PDPK1.
Cellular Location: Cytoplasm. Nucleus.

Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD (PubMed:15799969). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236).
Database Links:
  • Entrez Gene: 4089?Human
  • Entrez Gene: 17128?Mouse
  • Entrez Gene: 50554?Rat
  • Omim: 600993?Human
  • SwissProt: Q13485?Human
  • SwissProt: P97471?Mouse
  • SwissProt: O70437?Rat
  • Unigene: 75862?Human
  • Unigene: 100399?Mouse
  • Unigene: 9774?Rat
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    Synonyms:
  • (Small) Mothers Against Decapentaplegic Antibody
  • Deleted in Pancreatic Carcinoma Antibody
  • Deleted in Pancreatic Carcinoma 4 Antibody
  • Deleted in pancreatic carcinoma locus 4 Antibody
  • Deletion target in pancreatic carcinoma 4 Antibody
  • DPC 4 Antibody
  • DPC4 Antibody
  • hSMAD4 Antibody
  • JIP Antibody
  • MAD homolog 4 Antibody
  • MAD mothers against decapentaplegic Drosophila homolog 4 Antibody
  • MAD mothers against decapentaplegic homolog 4 Antibody
  • MADH 4 Antibody
  • MADH4 Antibody
  • Med Antibody
  • Medea Antibody
  • Mothers against decapentaplegic homolog 4 Antibody
  • Mothers against decapentaplegic, Drosophila, homolog of, 4 Antibody
  • Mothers against DPP homolog 4 Antibody
  • MYHRS Antibody
  • OTTHUMP00000163548 Antibody
  • SMA- and MAD-related protein 4 Antibody
  • SMAD 4 Antibody
  • SMAD family member 4 Antibody
  • SMAD mothers against DPP homolog 4 Antibody
  • Smad4 Antibody
  • SMAD4_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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