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Anti-EGFR Antibody

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产品名称: Anti-EGFR Antibody
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简单介绍

Anti-EGFR Antibody


Anti-EGFR Antibody  的详细介绍
Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5. Sumoylates p53/TP53 at 'Lys-386' (By similarity).
Tissue Specificity: Broadly expressed, with highest levels in spleen and lung (at protein level).
Sequence Similarities: Belongs to the ubiquitin-conjugating enzyme family.
Post-Translational Modification: Phosphorylation at Ser-71 significantly enhances SUMOylation activity.
Cellular Location: Nucleus. Cytoplasm.

Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity).
Database Links:
  • Entrez Gene: 7329 Human
  • Entrez Gene: 100044900 Mouse
  • Entrez Gene: 22196 Mouse
  • Entrez Gene: 25573 Rat
  • Omim: 601661 Human
  • SwissProt: P63279 Human
  • SwissProt: P63280 Mouse
  • SwissProt: P63281 Rat
  • Unigene: 302903 Human
  • Unigene: 240044 Mouse
  • Unigene: 384234 Mouse
  • Unigene: 442797 Mouse
  • Unigene: 2274 Rat
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    Synonyms:
  • C358B7.1 Antibody
  • p18 Antibody
  • SUMO 1 protein ligase Antibody
  • SUMO conjugating enzyme UBC9 Antibody
  • SUMO-conjugating enzyme UBC9 Antibody
  • SUMO-protein ligase Antibody
  • SUMO1 protein ligase Antibody
  • UBC9 Antibody
  • UBC9_HUMAN Antibody
  • UBCE9 Antibody
  • Ube2i Antibody
  • UBE2I / UBC9 Antibody
  • Ubiquitin carrier protein Antibody
  • Ubiquitin carrier protein 9 Antibody
  • Ubiquitin carrier protein I Antibody
  • Ubiquitin conjugating enzyme 9 Antibody
  • Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9) Antibody
  • Ubiquitin conjugating enzyme E2I (UBC9 homolog, yeast) Antibody
  • Ubiquitin conjugating enzyme UbcE2A Antibody
  • Ubiquitin like protein SUMO 1 conjugating enzyme Antibody
  • Ubiquitin protein ligase E2I Antibody
  • Ubiquitin-conjugating enzyme E2 I Antibody
  • Ubiquitin-protein ligase I Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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