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Anti-SOCS1 Antibody

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产品名称: Anti-SOCS1 Antibody
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简单介绍

Anti-SOCS1 Antibody


Anti-SOCS1 Antibody  的详细介绍
Name: Anti-SOCS1 Antibody
See all SOCS1 primary antibodies
Description: Goat polyclonal antibody to SOCS1.
Applications: ELISA, WB
Reactivity: Mouse, Human
Immunogen: Synthetic peptide corresponding to Human SOCS1 (C terminal).
Sequence: C-VLRDYLSSFPFQI
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity).
Tissue Specificity: High expression in thymus. Lower expression in lung and spleen. Expressed in both Th1 and Th2 cells.
Sequence Similarities: Belongs to the SOCS1 family.
Cellular Location: Nucleus. Cytoplasmic vesicle.

Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Database Links:
  • Entrez Gene: 8651 Human
  • Entrez Gene: 12703 Mouse
  • Omim: 603597 Human
  • SwissProt: O15524 Human
  • SwissProt: O35716 Mouse
  • Unigene: 50640 Human
  • Unigene: 130 Mouse
    		•
    Synonyms:
  • CISH 1 Antibody
  • CISH1 Antibody
  • Cytokine inducible SH2 protein 1 Antibody
  • JAB Antibody
  • JAK binding protein Antibody
  • JAK-binding protein Antibody
  • Janus kinase binding protein Antibody
  • SOCS 1 Antibody
  • SOCS-1 Antibody
  • SOCS1 Antibody
  • SOCS1_HUMAN Antibody
  • SSI 1 Antibody
  • SSI-1 Antibody
  • SSI1 Antibody
  • STAT induced STAT inhibitor 1 Antibody
  • STAT-induced STAT inhibitor 1 Antibody
  • Suppressor of cytokine signaling 1 Antibody
  • Supressor of cytokine signalling 1 Antibody
  • TEC interacting protein 3 Antibody
  • Tec-interacting protein 3 Antibody
  • TIP 3 Antibody
  • TIP-3 Antibody
  • TIP3 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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