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Anti-Smad2 (phospho-S467) Antibody

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产品名称: Anti-Smad2 (phospho-S467) Antibody
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Anti-Smad2 (phospho-S467) Antibody


Anti-Smad2 (phospho-S467) Antibody  的详细介绍
Name: Anti-Smad2 (phospho-S467) Antibody
See all Smad2 primary antibodies
Description: Rabbit polyclonal antibody to Smad2 (phospho-S467)
Specificity: p-Smad2 (S467) pAb detects endogenous levels of Smad2 protein only when phosphorylated at Ser467.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human Smad2 around the phosphorylation site of Serine 467.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 60 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Tissue Specificity: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
Sequence Similarities: Belongs to the dwarfin/SMAD family.
Post-Translational Modification: Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases. TGF-beta-induced Ser-465/467 phosphorylation declines progressively in a KMT5A-dependent manner. Able to interact with SMURF2 when phosphorylated on Ser-465/467, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1.
Cellular Location: Cytoplasm. Nucleus.

Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081).
Database Links:
  • Entrez Gene: 4087?Human
  • Entrez Gene: 17126?Mouse
  • Entrez Gene: 29357?Rat
  • Omim: 601366?Human
  • SwissProt: Q15796?Human
  • SwissProt: Q62432?Mouse
  • SwissProt: O70436?Rat
  • Unigene: 12253?Human
  • Unigene: 705764?Human
  • Unigene: 152699?Mouse
  • Unigene: 391091?Mouse
  • Unigene: 2755?Rat
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    Synonyms:
  • Drosophila, homolog of, MADR2 Antibody
  • hMAD-2 Antibody
  • HsMAD2 Antibody
  • JV18 Antibody
  • JV18-1 Antibody
  • JV181 Antibody
  • MAD Antibody
  • MAD homolog 2 Antibody
  • MAD Related Protein 2 Antibody
  • Mad-related protein 2 Antibody
  • MADH2 Antibody
  • MADR2 Antibody
  • MGC22139 Antibody
  • MGC34440 Antibody
  • Mother against DPP homolog 2 Antibody
  • Mothers against decapentaplegic homolog 2 Antibody
  • Mothers against decapentaplegic, Drosophila, homolog of, 2 Antibody
  • Mothers against DPP homolog 2 Antibody
  • OTTHUMP00000163489 Antibody
  • Sma and Mad related protein 2 Antibody
  • Sma- and Mad-related protein 2 MAD Antibody
  • SMAD 2 Antibody
  • SMAD family member 2 Antibody
  • SMAD, mothers against DPP homolog 2 Antibody
  • Smad2 Antibody
  • SMAD2_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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