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Anti-RARA Antibody

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产品名称: Anti-RARA Antibody
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简单介绍

Anti-RARA Antibody


Anti-RARA Antibody  的详细介绍
Name: Anti-RARA Antibody
See all RARA primary antibodies
Description: Goat polyclonal antibody to RARA.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human RARA (C terminal).
Sequence: C-SPSLSPSSHRSSPATQSP
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.
Post-Translational Modification: Phosphorylated on serine and threonine residues. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity (By similarity). Phosphorylation by AKT1 is required for the repressor activity but has no effect on DNA binding, protein stability nor subcellular localization. Phosphorylated by PKA in vitro. This phosphorylation on Ser-219 and Ser-369 is critical for ligand binding, nuclear localization and transcriptional activity in response to FSH signaling.
Cellular Location: Nucleus. Cytoplasm.

Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation.
Database Links:
  • Entrez Gene: 5914 Human
  • Omim: 180240 Human
  • SwissProt: P10276 Human
  • Unigene: 654583 Human
    		•
    Synonyms:
  • NR1B1 Antibody
  • Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein Antibody
  • Nuclear receptor subfamily 1 group B member 1 Antibody
  • Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form Antibody
  • RAR Antibody
  • RAR alpha Antibody
  • RAR-alpha Antibody
  • rara Antibody
  • RARalpha Antibody
  • RARalpha1 Antibody
  • RARA_HUMAN Antibody
  • Retinoic acid nuclear receptor alpha variant 1 Antibody
  • Retinoic acid nuclear receptor alpha variant 2 Antibody
  • Retinoic Acid Receptor alpha Antibody
  • Retinoic acid receptor alpha polypeptide Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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