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Anti-CREB (phospho-S133) Antibody

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产品名称: Anti-CREB (phospho-S133) Antibody
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Anti-CREB (phospho-S133) Antibody


Anti-CREB (phospho-S133) Antibody  的详细介绍
Name: Anti-CREB (phospho-S133) Antibody
See all CREB primary antibodies
Description: Rabbit polyclonal antibody to CREB (phospho-S133)
Specificity: p-CREB (S133) pAb detects endogenous levels of CREB protein when phosphorylated at Ser133.
Applications: WB, IHC, IP
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human CREB around the phosphorylation site of Serine 133.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 38 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Function: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Involvement in Disease: Angiomatoid fibrous histiocytoma: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
Sequence Similarities: Belongs to the bZIP family.
Post-Translational Modification: Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 1385?Human
  • Entrez Gene: 12912?Mouse
  • Entrez Gene: 81646?Rat
  • Omim: 123810?Human
  • SwissProt: P16220?Human
  • SwissProt: Q01147?Mouse
  • SwissProt: P15337?Rat
  • Unigene: 516646?Human
  • Unigene: 453295?Mouse
  • Unigene: 90061?Rat
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    Synonyms:
  • Active transcription factor CREB Antibody
  • cAMP response element binding protein Antibody
  • cAMP response element binding protein 1 Antibody
  • cAMP responsive element binding protein 1 Antibody
  • cAMP-responsive element-binding protein 1 Antibody
  • CREB Antibody
  • CREB-1 Antibody
  • CREB1 Antibody
  • CREB1_HUMAN Antibody
  • Cyclic AMP-responsive element-binding protein 1 Antibody
  • MGC9284 Antibody
  • OTTHUMP00000163864 Antibody
  • OTTHUMP00000163865 Antibody
  • OTTHUMP00000206660 Antibody
  • OTTHUMP00000206662 Antibody
  • OTTHUMP00000206667 Antibody
  • Transactivator protein Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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