Anti-CD271 Antibody

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产品名称: Anti-CD271 Antibody

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Anti-CD271 Antibody

Anti-CD271 Antibody 的详细介绍

Overview

Name:	Anti-CD271 Antibody See all CD271 primary antibodies
Description:	Mouse monoclonal (NGFR5) antibody to CD271.
Specificity:	The mouse monoclonal antibody NGFR5 (originally C34C) recognizes CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily. The epitope is localized within ammino acids 1 - 160.
Applications:	FC, IP, WB, IHC-P, ICC
Reactivity:	Human, Non-Human Primates, Cat, Rabbit, Ferret
Immunogen:	Purified CD271 protein isolated from human melanoma cell line A875.
Host:	Mouse
Clonality:	Monoclonal
Clone:	NGFR5
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Target

Introduction:

CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.

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