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Anti-ATF4 Antibody

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产品名称: Anti-ATF4 Antibody
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简单介绍

Anti-ATF4 Antibody


Anti-ATF4 Antibody  的详细介绍
Name: Anti-ATF4 Antibody
See all ATF-4 primary antibodies
Description: Goat polyclonal antibody to ATF4.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human ATF4 (C terminal).
Sequence: C-EEVRKARGKKRVP
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).
Sequence Similarities: Belongs to the bZIP family.
Post-Translational Modification: Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4.
Cellular Location: Cytoplasm. Cell membrane. Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.

Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783).
Database Links:
  • Entrez Gene: 468 Human
  • Omim: 604064 Human
  • SwissProt: P18848 Human
  • Unigene: 496487 Human
    		•
    Synonyms:
  • Activating transcription factor 4 Antibody
  • ATF 4 Antibody
  • ATF-4 Antibody
  • ATF4 Antibody
  • ATF4 protein Antibody
  • ATF4_HUMAN Antibody
  • cAMP-dependent transcription factor ATF-4 Antibody
  • cAMP-responsive element-binding protein 2 Antibody
  • CREB 2 Antibody
  • CREB-2 Antibody
  • CREB2 Antibody
  • Cyclic AMP dependent transcription factor ATF 4 Antibody
  • Cyclic AMP response element binding protein 2 Antibody
  • Cyclic AMP-dependent transcription factor ATF-4 Antibody
  • Cyclic AMP-responsive element-binding protein 2 Antibody
  • DNA binding protein TAXREB67 Antibody
  • DNA-binding protein TAXREB67 Antibody
  • Tax Responsive Enhancer Element B67 Antibody
  • Tax-responsive enhancer element-binding protein 67 Antibody
  • TaxREB67 Antibody
  • TXREB Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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