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Anti-TRAF6 (H154) Antibody

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产品名称: Anti-TRAF6 (H154) Antibody
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Anti-TRAF6 (H154) Antibody


Anti-TRAF6 (H154) Antibody  的详细介绍
Name: Anti-TRAF6 (H154) Antibody
See all TRAF6 primary antibodies
Description: Rabbit polyclonal antibody to TRAF6 (H154)
Specificity: TRAF6 (H154) pAb detects endogenous levels of TRAF6 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 122-170 of Human TRAF6.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 58 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
Tissue Specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Sequence Similarities: Belongs to the TNF receptor-associated factor family. A subfamily.
Post-Translational Modification: Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1.
Cellular Location: Cytoplasm. Cytoplasm > Cell cortex. Nucleus. Lipid droplet.

Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity).
Database Links:
  • Entrez Gene: 7189?Human
  • Entrez Gene: 22034?Mouse
  • Entrez Gene: 311245?Rat
  • Omim: 602355?Human
  • SwissProt: Q9Y4K3?Human
  • SwissProt: P70196?Mouse
  • SwissProt: B5DF45?Rat
  • Unigene: 444172?Human
  • Unigene: 591983?Human
  • Unigene: 292729?Mouse
  • Unigene: 220435?Rat
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    Synonyms:
  • E3 ubiquitin-protein ligase TRAF6 Antibody
  • Interleukin 1 signal transducer Antibody
  • Interleukin-1 signal transducer Antibody
  • MGC 3310 Antibody
  • MGC3310 Antibody
  • MGC:3310 Antibody
  • OTTHUMP00000232772 Antibody
  • OTTHUMP00000232773 Antibody
  • RING finger protein 85 Antibody
  • RNF 85 Antibody
  • RNF85 Antibody
  • TNF receptor associated factor 6 Antibody
  • TNF receptor-associated factor 6 Antibody
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase Antibody
  • TRAF 6 Antibody
  • TRAF6 Antibody
  • TRAF6_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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