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Anti-UMOD Antibody

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简单介绍

Anti-UMOD Antibody


Anti-UMOD Antibody  的详细介绍
Name: Anti-UMOD Antibody
See all UMOD primary antibodies
Description: Goat polyclonal antibody to UMOD.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human UMOD (internal region).
Sequence: DRCPHTRDSTIQ
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515).
Tissue Specificity: Expressed in the tubular cells of the kidney. Most abundant protein in normal urine (at protein level). Synthesized exclusively in the kidney. Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen.
Involvement in Disease: Familial juvenile hyperuricemic nephropathy 1: A renal disease characterized by juvenile onset of hyperuricemia, polyuria, progressive renal failure, and gout. The disease is associated with interstitial pathological changes resulting in fibrosis.

Medullary cystic kidney disease 2: A form of tubulointerstitial nephropathy characterized by formation of renal cysts at the corticomedullary junction. It is characterized by ***** onset of impaired renal function and salt wasting resulting in end-stage renal failure by the sixth decade.

Glomerulocystic kidney disease with hyperuricemia and isosthenuria: A renal disorder characterized by a cystic dilation of Bowman space, a collapse of glomerular tuft, and hyperuricemia due to low fractional excretion of uric acid and severe impairment of urine concentrating ability.
Post-Translational Modification: N-glycosylated (PubMed:19005207, PubMed:26673890, PubMed:26811476). N-glycan heterogeneity at Asn-232: Hex7HexNAc6 (major) and dHex1Hex7HexNAc6 (minor); at Asn-322: dHex1Hex6HexNAc5 (minor), dHex1Hex7HexNAc6 (major) and dHex1Hex8HexNAc7 (minor); at Asn-396: Hex6HexNAc5 (major), dHex1Hex6HexNAc5 (minor) and Hex7HexNAc6 (minor) (PubMed:22171320).
Cellular Location: Apical cell membrane. Basolateral cell membrane. Cell projection > Cilium membrane.

Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization (PubMed:22776760). Secreted into urine after cleavage (PubMed:18375198, PubMed:26811476). Colocalizes with NPHP1 and KIF3A (PubMed:20172860).
Database Links:
  • Entrez Gene: 7369 Human
  • Omim: 191845 Human
  • SwissProt: P07911 Human
  • Unigene: 654425 Human
    		•
    Synonyms:
  • ADMCKD2 Antibody
  • FJHN Antibody
  • HNFJ Antibody
  • HNFJ1 Antibody
  • MCKD2 Antibody
  • medullary cystic kidney disease 2 (autosomal dominant) Antibody
  • Tamm Horsfall glycoprotein Antibody
  • Tamm Horsfall urinary glycoprotein Antibody
  • Tamm-Horsfall urinary glycoprotein Antibody
  • THGP Antibody
  • THP Antibody
  • Umod Antibody
  • Urehd1 Antibody
  • urehr4 Antibody
  • Uromodulin Antibody
  • uromodulin (uromucoid, Tamm-Horsfall glycoprotein) Antibody
  • Uromodulin, secreted form Antibody
  • Uromucoid Antibody
  • UROM_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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