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Anti-UBR5 Antibody

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产品名称: Anti-UBR5 Antibody
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简单介绍

Anti-UBR5 Antibody


Anti-UBR5 Antibody  的详细介绍
Name: Anti-UBR5 Antibody
See all UBR5 primary antibodies
Description: Goat polyclonal antibody to UBR5.
Applications: ELISA, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human UBR5 (C terminal).
Sequence: C-LAIKTKNFGFV
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Tissue Specificity: Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 51366?Human
  • Omim: 608413?Human
  • SwissProt: O95071?Human
  • Unigene: 492445?Human
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    Synonyms:
  • 4432411E13Rik Antibody
  • AW549941 Antibody
  • C77315 Antibody
  • D030042K14 Antibody
  • DD5 Antibody
  • E3 identified by differential display Antibody
  • E3 ubiquitin protein ligase, HECT domain containing, 1 Antibody
  • E3 ubiquitin-protein ligase Antibody
  • E3 ubiquitin-protein ligase UBR5 Antibody
  • EDD Antibody
  • EDD 1 Antibody
  • EDD1 Antibody
  • FLJ11310 Antibody
  • HECT domain-containing 1 Antibody
  • hHYD Antibody
  • HYD Antibody
  • Hyperplastic discs protein homolog Antibody
  • Hyperplastic discs, Drosophila, homolog of Antibody
  • KIAA0896 Antibody
  • MGC57263 Antibody
  • mKIAA0896 Antibody
  • Progestin induced protein Antibody
  • Progestin-induced protein Antibody
  • Rat100 Antibody
  • Ubiquitin protein ligase Antibody
  • Ubiquitin protein ligase E3 component n recognin 5 Antibody
  • UBR5 Antibody
  • UBR5_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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